The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats.
The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats.
复制标题
肝水解物对正常大鼠慢性乙醇性肝损伤的影响。
DOI：
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发表时间：
2020
影响因子：
2
通讯作者：
M. Komai
中科院分区：
文献类型：
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作者：
Kotaro Yamada;Kazuma Ueda;H. Shirakawa;P. E. Giriwono;S. Honda;H. Sakurai;M. Komai
乙醇诱导的肝损伤后肝水解物（LH）改善肝功能的机制尚不清楚。因此，我们研究了LH给药对正常大鼠慢性乙醇诱导的肝损伤的影响，以及LH改善其症状的机制。LH减轻了正常大鼠慢性乙醇诱导的肝损伤后的肝损伤，降低了氧化应激。LH治疗降低了血浆天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的肝损伤生物标志物。LH处理还降低了作为氧化应激标志物的8-羟基-脱氧鸟苷（8-OHdG）的水平。LH可能被证明是有益的，以防止慢性乙醇的肝损伤，至少在一定程度上，通过减轻氧化应激。
The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH.LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.
DOI：
10.1111/j.1530-0277.2001.tb02273.x
发表时间：
2001-05-01
影响因子：
3.2
作者：
Bailey, SM;Patel, VB;Cunningham, CC
通讯作者：
Cunningham, CC