Electrostatic powder coated osmotic pump tablets: Influence factors of coating powder adhesion and film formation
Electrostatic powder coated osmotic pump tablets: Influence factors of coating powder adhesion and film formation
复制标题
静电粉末包衣渗透泵片：包衣粉末附着力和成膜的影响因素
DOI：
10.1016/j.powtec.2019.10.084
复制
发表时间：
2020-01
影响因子：
5.2
通讯作者：
Jesse Zhu
中科院分区：
文献类型：
--
作者：
Qingliang Yang;Feng Yuan;Yingliang Ma;Kaiqi Shi;Gensheng Yang;Jesse Zhu
渗透泵片剂静电粉末包衣由于其干燥包衣工艺，在医药工业中越来越受到重视。本研究旨在探讨超细粉末对渗透泵片静电粉末包衣在粉末附着和成膜过程中的影响因素。粉末附着力评价结果表明，液体增塑剂和静电喷枪的充电电压对粉末附着力有显著影响。扫描电镜和药物溶出度测试表明，涂层粒度和固化时间、温度对成膜过程有显著影响，更细的涂层粒度和更高的固化温度、更长的固化时间可以使涂层更连续、更均匀。这些结果表明，通过精心设计的静电粉末涂层可以制备出高质量的可控涂层，这表明它是制备渗透给药系统的有前途的替代方案。
Electrostatic powder coating of osmotic pump tablets becomes increasingly attractive in pharmaceutical industry due to its dry coating process. The present study aimed to investigate the influence factors of electrostatic powder coating of osmotic pump tablets with ultrafine powders during the powder adhesion and film formation. The results of the powder adhesion evaluation indicated that the powder adhesion was significantly influenced by the liquid plasticizers and the charging voltage of the electrostatic spray gun. SEM and drug dissolution tests illustrated that coating particle size and curing time and temperature could significantly influenced the film formation process, a finer coating particle size and-/or higher curing temperature and-/or longer curing time led to a more continuous and uniform coating film. Those results indicate that a well-controlled coating film with high qualities could be fabricated by a well-designed electrostatic powder coating, suggesting it is a promising alternative for preparing osmotic drug delivery systems.
登录
查看更多内容
影响因子：
5.2
作者：
Yulu Wang;Dongguang Wei;R. Davé;R. Pfeffer;M. Sauceau;J. Letourneau;J. Fages
通讯作者：
Yulu Wang;Dongguang Wei;R. Davé;R. Pfeffer;M. Sauceau;J. Letourneau;J. Fages
影响因子：
5.8
作者：
M. Cerea;Weijia Zheng;C. R. Young;J. Mcginity
通讯作者：
M. Cerea;Weijia Zheng;C. R. Young;J. Mcginity
影响因子：
3.8
作者：
Hao Chen;Shuai Shi;Aina Liu;Xing Tang
通讯作者：
Hao Chen;Shuai Shi;Aina Liu;Xing Tang
DOI：
10.1016/j.ejpb.2010.06.009
发表时间：
2010-10
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Mingxi Qiao;Liqiang Zhang;Yingliang Ma;Jesse Zhu;Kwok Chow
通讯作者：
Mingxi Qiao;Liqiang Zhang;Yingliang Ma;Jesse Zhu;Kwok Chow
影响因子：
3.4
作者：
Nantharat Pearnchob;J. Siepmann;R. Bodmeier
通讯作者：
Nantharat Pearnchob;J. Siepmann;R. Bodmeier