The effect of tDCS on functional connectivity in primary progressive aphasia.
The effect of tDCS on functional connectivity in primary progressive aphasia.
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DOI：
10.1016/j.nicl.2018.05.023
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Tsapkini K
中科院分区：
文献类型：
--
作者：
Ficek BN;Wang Z;Zhao Y;Webster KT;Desmond JE;Hillis AE;Frangakis C;Vasconcellos Faria A;Caffo B;Tsapkini K
经颅直流电刺激（tDCS）是一种创新技术，最近被证明可以改善语言结果，即使在神经退行性疾病，如原发性进行性失语症（PPA），但潜在的大脑机制尚不清楚。本研究测试了PPA中重复tDCS（假手术）的额外语言增益是否是由刺激区域（左额下回（IFG））和语言网络其余部分之间的功能连接变化引起的。我们用静息态fMRI序列扫描了24名PPA参与者（11名女性）在语言干预（书面命名/拼写）前后的变化，并比较了三周tDCS或假手术与语言治疗相结合前后的变化。我们将语言网络和默认模式网络（DMN）的变化与语言治疗结果指标（书面命名中的字母准确性）相关联。在刺激区与其他语言网络区之间以及语言网络与DMN之间的功能连接中观察到显著的tDCS效应。左侧IFG上的TDCS降低了上述对之间的连通性。功能连接的变化与治疗前后评估的语言评分（字母准确性作为书面命名的代理）的改善相关。这些结果表明，PPA中左侧IFG上的阳极tDCS的一种机制是刺激部位与语言网络的其他后部区域之间的功能连接性降低（与假手术相比）。这些结果与在老化和其他神经退行性疾病中tDCS后观察到的连接性相对于左侧IFG的类似降低一致。提出了PPA中tDCS超过左侧IFG的脑机制。功能连接的变化之间的刺激和颞区。功能连接的变化与语言治疗结果相关。这是第一项为PPA中的tDCS机制提供证据的研究。
Transcranial direct current stimulation (tDCS) is an innovative technique recently shown to improve language outcomes even in neurodegenerative conditions such as primary progressive aphasia (PPA), but the underlying brain mechanisms are not known. The present study tested whether the additional language gains with repetitive tDCS (over sham) in PPA are caused by changes in functional connectivity between the stimulated area (the left inferior frontal gyrus (IFG)) and the rest of the language network. We scanned 24 PPA participants (11 female) before and after language intervention (written naming/spelling) with a resting-state fMRI sequence and compared changes before and after three weeks of tDCS or sham coupled with language therapy. We correlated changes in the language network as well as in the default mode network (DMN) with language therapy outcome measures (letter accuracy in written naming). Significant tDCS effects in functional connectivity were observed between the stimulated area and other language network areas and between the language network and the DMN. TDCS over the left IFG lowered the connectivity between the above pairs. Changes in functional connectivity correlated with improvement in language scores (letter accuracy as a proxy for written naming) evaluated before and after therapy. These results suggest that one mechanism for anodal tDCS over the left IFG in PPA is a decrease in functional connectivity (compared to sham) between the stimulated site and other posterior areas of the language network. These results are in line with similar decreases in connectivity observed after tDCS over the left IFG in aging and other neurodegenerative conditions. A brain mechanism for tDCS over the left IFG in PPA is proposed. Functional connectivity changes only between the stimulated and temporal areas. Changes in functional connectivity correlate with language therapy outcomes. This is the first study providing evidence for tDCS mechanisms in PPA.
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影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
5.7
作者：
Faria, Andreia V.;Joel, Suresh E.;Zhang, Yajing;Oishi, Kenichi;van Zjil, Peter C. M.;Miller, Michael I.;Pekar, James J.;Mori, Susumu
通讯作者：
Mori, Susumu