Numerical and experimental simulation of the effect of long bone fracture healing stages on ultrasound transmission across an idealized fracture
Numerical and experimental simulation of the effect of long bone fracture healing stages on ultrasound transmission across an idealized fracture
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DOI：
10.1121/1.3158938
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发表时间：
2009-08-01
影响因子：
2.4
通讯作者：
Cunningham, J. L.
中科院分区：
文献类型：
--
作者：
Gheduzzi, S.;Dodd, S. P.;Cunningham, J. L.
骨折愈合的各个阶段对沿着皮质骨板和穿过理想骨折传播的200 kHz超声波的振幅的影响已经被数值模拟和实验模拟。一个简单的，充满水，横向骨折被用来模拟炎症阶段。接下来，添加对称的外部愈伤组织以代表修复阶段，而减小尺寸的愈伤组织用于模拟重塑阶段。计算骨折部位上的首次到达信号幅度的变化，并与完整接骨板的数据进行比较，以计算以分贝为单位的骨折传输损耗（FTL）。骨痂的加入减少了骨折丢失。计算出最显著的变化发生在从初始炎症阶段到愈伤组织形成（FTL从6.3降低到5.5和3.5 dB之间，这取决于愈伤组织的性质）和重塑阶段，在重塑阶段，愈伤组织的大小减少50%后，FTL降低到2.0和1.3 dB之间。定性地，实验结果遵循模型预测。信号幅度随骨痂几何形状和弹性特性的变化可能用于监测愈合过程。(C)2009年，美国声学学会。[DOI 10.1121/1.3158938]
The effect of various stages of fracture healing on the amplitude of 200 kHz ultrasonic waves propagating along cortical bone plates and across an idealized fracture has been modeled numerically and experimentally. A simple, water-filled, transverse fracture was used to simulate the inflammatory stage. Next, a symmetric external callus was added to represent the repair stage, while a callus of reducing size was used to simulate the remodeling stage. The variation in the first arrival signal amplitude across the fracture site was calculated and compared with data for an intact plate in order to calculate the fracture transmission loss (FTL) in decibels. The inclusion of the callus reduced the fracture loss. The most significant changes were calculated to occur from the initial inflammatory phase to the formation of a callus (with the FTL reducing from 6.3 to between 5.5 and 3.5 dB, depending on them properties of the callus) and in the remodeling phase where, after a 50% reduction in the size of the callus, the FTL reduced to between 2.0 and 1.3 dB. Qualitatively, the experimental results follow the model predictions. The change in signal amplitude with callus geometry and elastic properties could potentially be used to monitor the healing process. (C) 2009 Acoustical Society of America. [DOI: 10.1121/1.3158938]