Co-delivery of ccl19 gene enhances anti-caries DNA vaccine pCIA-P immunogenicity in mice by increasing dendritic cell migration to secondary lymphoid tissues

Co-delivery of ccl19 gene enhances anti-caries DNA vaccine pCIA-P immunogenicity in mice by increasing dendritic cell migration to secondary lymphoid tissues
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ccl19基因的共同传递通过增加树突状细胞向次级淋巴组织的迁移来增强抗龋齿DNA疫苗pCIA-P在小鼠中的免疫原性

DOI:
10.1038/aps.2012.153
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发表时间:
2013-01
影响因子:
8.2
通讯作者:
Fan, Ming-wen
Fan, Ming-wen
中科院分区:
医学1区
文献类型:
--
作者:
Yan, Yan-hong;Qi, Sheng-cai;Su, Ling-kai;Xu, Qing-an;Fan, Ming-wen

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目的:研究C-C趋化因子配体19(CCL 19)基因共转染对防龋DNA疫苗pCIA-P诱导的小鼠全身免疫应答的影响。
Aim:To investigate how co-delivery of the gene encoding C–C chemokine ligand-19 (CCL-19) affected the systemic immune responses to an anti-caries DNA vaccine pCIA-P in mice.Methods:Plasmid encoding CCL19-GFP fusion protein (pCCL19/GFP) was constructed by
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