Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae
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DOI：
10.1212/01.wnl.0000142971.08275.db
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发表时间：
2004-11-09
期刊：
影响因子：
9.9
通讯作者：
Ohta, S
中科院分区：
文献类型：
--
作者：
Suzuki, Y;Fujisawa, M;Ohta, S
作者研究了酒精脱氢酶2(ADH2)基因与日本社区居民(1,102名男性/1,093名女性)血管事件的相关性。等位基因ADH2*2编码的同工酶比ADH2*1具有更高的活性水平。在这里，作者表明ADH2*1携带者与男性脑梗塞和腔隙的高患病率有关。多元回归分析证实，ADH2*1等位基因增加腔隙和脑梗塞的风险。
The authors examined the association of the alcohol dehydrogenase 2 (ADH2) genotype with vascular events in community-dwelling Japanese (1,102 men/1,093 women). The allele ADH2*2 encodes an isozyme with a higher level of activity than ADH2*1. Here, the authors show that the ADH2*1 carriage is associated with high prevalence of cerebral infarction and lacunae in men. Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele.