Desymmetrization of Cyclohexadienones via Asymmetric Michael Reaction Catalyzed by Cinchonine-Derived Urea
Desymmetrization of Cyclohexadienones via Asymmetric Michael Reaction Catalyzed by Cinchonine-Derived Urea
复制标题
辛可宁尿素催化不对称迈克尔反应去对称化环己二烯酮
DOI：
10.1021/ol202073p
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发表时间：
2011-10-07
期刊：
影响因子：
5.2
通讯作者：
You, Shu-Li
中科院分区：
文献类型：
--
作者：
Gu, Qing;You, Shu-Li
通过辛可宁衍生脲催化的不对称迈克尔反应，实现了带有双苯磺酰亚甲基的环己二酮的去对称化，以高收率和ee值提供了一系列高度对映体富集的多环环己烯酮。
Desymmetrization of cyclohexadienones bearing a bisphenylsulfonyl methylene group via asymmetric Michael reaction catalyzed by cinchonine-derived urea was realized to afford a series of highly enantioenriched polycyclic cyclohexenones in high yields and ee's.