The Q-TWiST approach to assessing health-related quality of life in epilepsy.
The Q-TWiST approach to assessing health-related quality of life in epilepsy.
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用于评估癫痫患者健康相关生活质量的 Q-TWiST 方法。
DOI：
10.1007/bf01833607
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Gelber,RD
中科院分区：
文献类型：
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作者：
Schwartz,CE;Cole,BF;Vickrey,BG;Gelber,RD
我们建议开发一种方法来评估癫痫临床干预措施对疾病相关结果、社会成本和生活质量的影响，同时纳入患者的偏好。该技术代表了“无症状和毒性质量调整时间”（Q-TWiST）方法的延伸，该方法之前曾用于评估癌症和艾滋病治疗的毒性成本以及改善无进展生存和总体生存的益处。我们建议开发的扩展允许将与癫痫相关的生活质量的其他维度纳入分析中。我们通过一个假设的例子来展示所提出的 Q-TWiST 方法的可能应用，该例子比较了手术与单独用于癫痫发作控制的抗癫痫药物管理。强调了这些替代治疗之间的权衡，以及关于生活质量各个方面的患者重要性权重。我们描述了充分开发该方法所需的进一步研究，并对其潜在用途进行了评论。
We propose to develop a methodology for evaluating clinical interventions for epilepsy in terms of their effects on disease-related outcomes, social cost and quality of life, while incorporating patient preference. The technique represents an extension of the ‘quality-adjusted time without symptoms and toxicities’ (Q-TWiST) method, which has been previously used to evaluate treatments for cancer and AIDS with respect to their costs in terms of toxicities, and benefits in terms of improved progression-free and overall survival. The extensions we propose to develop allow additional dimensions of quality of life relevant to epilepsy to be included in the analysis. We demonstrate a possible application of the proposed Q-TWiST method with a hypothetical example comparing surgeryvsantiepileptic medication management alone for seizure control. The trade-offs between these alternative treatments are highlighted, along with patient importance weightings regarding various dimensions of quality of life. We describe further research needed to develop the methodology fully and comment on its potential usefulness.