Distribution of anti-F(ab')2 antibodies and the 16/6 idiotype in systemic lupus erythematosus (SLE) probands and kindreds.
Distribution of anti-F(ab')2 antibodies and the 16/6 idiotype in systemic lupus erythematosus (SLE) probands and kindreds.
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抗 F(ab)2 抗体和 16/6 独特型在系统性红斑狼疮 (SLE) 先证者和亲属中的分布。
DOI：
10.1007/bf00918015
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发表时间：
1989
影响因子：
9.1
通讯作者：
Schwartz,RS
中科院分区：
文献类型：
--
作者：
Silvestris,F;Searles,RA;WilliamsJr,RC;Rodriguez,MA;Schwartz,RS
对17例系统性红斑狼疮（SLE）患者一级亲属103份血清中抗F（ab′）2抗体水平及16/6抗DNA独特型的表达进行了研究。在SLE患者中，抗F（ab′）2抗体阳性率为35.9%，Id 16/6抗体阳性率为24%。43.2%的抗F（ab′）2升高的健康SLE亲属也显示16/6的表达;当Id 16/6阳性时，25名亲属中有16名（64%）显示抗F（ab′）2平行升高。然而，在个别家族内，抗F（ab '）2和Id 16/6升高的分布模式往往不一致。从一个SLE家系的4个成员中亲和分离的抗F（ab′）2抗体显示，在所研究的4个个体中，只有2个个体的Id 16/6相对富集。此外，在这个家族或另一个显示16/6 Id表达的家族中，没有分离的抗F（ab′）2抗体直接与16/6 Id反应。我们的研究表明，尽管抗F（ab′）2和Id 16/6在SLE激酶中均增加，但两者的表达并不总是一致的。抗F（ab′）2抗体与Id 16/6无直接反应性。一些抗DNA独特型标记物可能在这种SLE激酶的独特型网络中发挥作用。
Levels of serum anti-F(ab′)2antibodies and expression of the 16/6 anti-DNA idiotype were studied in 103 sera from first-degree relatives of 17 systemic lupus erythematosus (SLE) kindreds. Among healthy SLE relatives, 35.9% showed anti-F(ab′)2elevations and 24%, Id 16/6 expression. Forty-three and two-tenths percent of healthy SLE relatives with elevated anti-F(ab′)2also showed expression of 16/6; when Id 16/6 was positive, 16 of 25 relatives (64%) showed parallel elevations of anti-F(ab′)2. However, within individual families, distribution patterns of elevated anti-F(ab′)2and Id 16/6 often did not coincide. Affinity-isolated anti-F(ab′)2from four members of a single SLE kindred showed relative enrichment for Id 16/6 in only two of the four individuals studied. Moreover, none of the isolated anti-F(ab′)2antibodies within this kindred or another kindred showing 16/6 Id expression reacted directly with 16/6 Id. Our studies suggest that whereas both anti-F(ab′)2and Id 16/6 are increased within SLE kindreds, expression of the two does not always coincide. Furthermore, anti-F(ab′)2antibodies do not show direct reactivity with Id 16/6. A number of anti-DNA idiotypic markers may play a role in idiotypic networks among such SLE kindreds.