Expression status and prognostic value of cancer / testis antigen OY-TES-1 in glioma
Expression status and prognostic value of cancer / testis antigen OY-TES-1 in glioma
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发表时间：
2016
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通讯作者：
Lei Shi;Qingmei Zhang;Zong-dang Wei;B. Luo;Jun Fu;Yanshen Peng;Q. Hu;Fang Chen;Ying-ying Ge;S. Xiao;Xiaoxun Xie
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作者：
Lei Shi;Qingmei Zhang;Zong-dang Wei;B. Luo;Jun Fu;Yanshen Peng;Q. Hu;Fang Chen;Ying-ying Ge;S. Xiao;Xiaoxun Xie
肿瘤睾丸抗原（Cancer Testis，CT）在正常组织中表达有限，在大多数肿瘤组织中过量表达，是肿瘤免疫治疗的重要靶点。OY-TES-1是癌症/睾丸（CT）抗原家族的成员。目前对OY-TES-1在胶质瘤中表达的研究多是在mRNA水平上。OY-TES-1蛋白在胶质瘤中的作用尚未被描述。本研究采用免疫组化方法检测124例脑胶质瘤组织中OY-TES-1蛋白的表达，并分析其与临床指标的相关性。并通过随访资料确定其对胶质瘤预后的临床意义。结果表明，OY-TES-1蛋白主要定位于细胞质和细胞核，在124例组织标本中总阳性率为69.35%。OY-TES-1的表达与WHO胶质瘤分级密切相关。Kaplan-Meier分析显示OY-TES-1表达与生存率呈显著负相关。OY-TES-1表达可能是预测胶质瘤进展和患者生存的候选生物标志物。
Cancer testis (CT) antigens are attractive therapeutic targets for tumor immunotherapy because of their restrictive expression in normal tissues and excessive in majority of tumor types. OY-TES-1 is a member of the cancer/testis (CT) antigen family. Current research about OY-TES-1 expression in glioma is practically at mRNA level. The role of OY-TES-1 protein in glioma has not yet been described. In this study, we detected OY-TES-1 protein expression in 124 samples from patients with glioma by immunohistochemistry and analyzed the correlation between OY-TES-1 expression and clinical indexes. Furthermore, its clinical significance on glioma prognosis was determined by followup data. Our results showed that the OY-TES-1 staining was mainly located in the cell cytoplasm and nucleus and the total positive rate of its protein was 69.35% in 124 isolated tissue samples. OY-TES-1 expression was closely related with the WHO glioma grade. Kaplan-Meier analysis revealed a significant negative correlation between OY-TES-1 expression and survival. OY-TES-1 expression may be a candidate biomarker for prediction of glioma progression and survival of patients.