New Insight Into Neutrophils: A Potential Therapeutic Target for Cerebral Ischemia.
New Insight Into Neutrophils: A Potential Therapeutic Target for Cerebral Ischemia.
复制标题
对中性粒细胞的新见解：脑缺血的潜在治疗靶点
DOI：
10.3389/fimmu.2021.692061
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Jian Z
中科院分区：
文献类型：
--
作者：
Chen R;Zhang X;Gu L;Zhu H;Zhong Y;Ye Y;Xiong X;Jian Z
缺血性脑卒中是全球威胁人类健康的主要问题之一，也是导致成人永久性残疾的主要原因。缺血性中风后能量消耗和缺氧导致神经细胞死亡，激活常驻胶质细胞，促进外周免疫细胞向大脑浸润，产生各种免疫介导效应甚至相互矛盾的效应。免疫细胞浸润可介导神经元凋亡、加重缺血性损伤，但也可促进神经元修复、分化和再生。中枢神经系统（CNS）是人体最重要的免疫特权部分之一，通过血脑屏障（BBB）与周围免疫系统分开。生理条件下，外周免疫细胞向中枢神经系统的浸润受血脑屏障控制，并受免疫细胞与血管内皮细胞相互作用的调节。由于免疫反应在调节缺血性损伤的发展中发挥着关键作用，中性粒细胞已被证明与许多炎症性疾病有关，尤其是急性缺血性中风（AIS）。然而，中性粒细胞可能在中枢神经系统中发挥双重作用。中性粒细胞是缺血性中风后第一批从外周进入大脑的免疫细胞，其在脑缺血中的确切作用还有待进一步探讨。阐明免疫细胞的特征及其在炎症反应调节中的作用可能会导致新的潜在治疗策略的确定。因此，本综述将具体讨论中性粒细胞从产生到功能分化在缺血性脑卒中中的作用，强调有前景的靶向干预措施，这可能会促进未来缺血性脑卒中治疗的发展。
Ischemic stroke is one of the main issues threatening human health worldwide, and it is also the main cause of permanent disability in adults. Energy consumption and hypoxia after ischemic stroke leads to the death of nerve cells, activate resident glial cells, and promote the infiltration of peripheral immune cells into the brain, resulting in various immune-mediated effects and even contradictory effects. Immune cell infiltration can mediate neuronal apoptosis and aggravate ischemic injury, but it can also promote neuronal repair, differentiation and regeneration. The central nervous system (CNS), which is one of the most important immune privileged parts of the human body, is separated from the peripheral immune system by the blood-brain barrier (BBB). Under physiological conditions, the infiltration of peripheral immune cells into the CNS is controlled by the BBB and regulated by the interaction between immune cells and vascular endothelial cells. As the immune response plays a key role in regulating the development of ischemic injury, neutrophils have been proven to be involved in many inflammatory diseases, especially acute ischemic stroke (AIS). However, neutrophils may play a dual role in the CNS. Neutrophils are the first group of immune cells to enter the brain from the periphery after ischemic stroke, and their exact role in cerebral ischemia remains to be further explored. Elucidating the characteristics of immune cells and their role in the regulation of the inflammatory response may lead to the identification of new potential therapeutic strategies. Thus, this review will specifically discuss the role of neutrophils in ischemic stroke from production to functional differentiation, emphasizing promising targeted interventions, which may promote the development of ischemic stroke treatments in the future.
登录
查看更多内容
影响因子：
1.5
作者：
Bafutto, Mauro;Oliveira, Enio Chaves;Rezende Filho, Joffre
通讯作者：
Rezende Filho, Joffre
影响因子：
20.1
作者：
Drechsler M;de Jong R;Rossaint J;Viola JR;Leoni G;Wang JM;Grommes J;Hinkel R;Kupatt C;Weber C;Döring Y;Zarbock A;Soehnlein O
通讯作者：
Soehnlein O
影响因子：
37.8
作者：
Baek AE;Sutton NR;Petrovic-Djergovic D;Liao H;Ray JJ;Park J;Kanthi Y;Pinsky DJ
通讯作者：
Pinsky DJ
影响因子：
20.3
作者：
Christopher, Matthew J.;Liu, Fulu;Link, Daniel C.
通讯作者：
Link, Daniel C.
影响因子：
4.3
作者：
Amantea D;Micieli G;Tassorelli C;Cuartero MI;Ballesteros I;Certo M;Moro MA;Lizasoain I;Bagetta G
通讯作者：
Bagetta G