Dorsal striatum responses to reward and punishment: Effects of valence and magnitude manipulations
Dorsal striatum responses to reward and punishment: Effects of valence and magnitude manipulations
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DOI：
10.3758/cabn.3.1.27
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发表时间：
2003-03-01
影响因子：
2.9
通讯作者：
Fiez, J. A.
中科院分区：
文献类型：
--
作者：
Delgado, M. R.;Locke, H. M.;Fiez, J. A.
这项研究的目的是进一步了解纹状体如何响应情感反馈的传递。此前，我们发现纹状体在给予金钱奖励后表现出持续激活的模式，与惩罚后血流动力学反应下降相反。在这项研究中，我们测试了纹状体的活动是否可以通过经济奖励或惩罚金额的参数变化来调节。我们使用了与事件相关的功能磁共振成像设计，参与者在完成赌博任务后获得或大或小的金钱奖励或惩罚。根据大小和价在背侧纹状体中观察到条件的参数排序。此外，在第二个实验中观察到了对反馈呈现的早期反应，并在时间分辨率提高的情况下复制了这一反应。这项研究进一步表明，背侧纹状体是负责控制动机行为的奖励回路的一个组成部分，用于编码效价和幅度等反馈特性。
The goal of this research was to further our understanding of how the striatum responds to the delivery of affective feedback. Previously, we had found that the striatum showed a pattern of sustained activation after presentation of a monetary reward, in contrast to a decrease in the hemodynamic response after a punishment. In this study, we tested whether the activity of the striatum could be modulated by parametric variations in the amount of financial reward or punishment. We used an event-related fMRI design in which participants received large or small monetary rewards or punishments after performance in a gambling task. A parametric ordering of conditions was observed in the dorsal striatum according to both magnitude and valence. In addition, an early response to the presentation of feedback was observed and replicated in a second experiment with increased temporal resolution. This study further implicates the dorsal striatum as an integral component of a reward circuitry responsible for the control of motivated behavior, serving to code for such feedback properties as valence and magnitude.