The emerging roles of prohibitins in folliculogenesis.
The emerging roles of prohibitins in folliculogenesis.
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DOI：
10.2741/410
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
I. Chowdhury;Minerva T. Garcia-Barrio;Djana Harp;K. Thomas;R. Matthews;W. Thompson
中科院分区：
文献类型：
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作者：
I. Chowdhury;Minerva T. Garcia-Barrio;Djana Harp;K. Thomas;R. Matthews;W. Thompson
抑制蛋白是高度保守的真核蛋白家族的成员，其包含在从原核生物到真核生物的不同物种中发现的气孔蛋白/抑制蛋白/漂浮蛋白/HflK/C（SPFH）结构域（也称为抑制蛋白（PHB）结构域）。在单细胞真核生物、真菌、植物、动物和人类中发现了抑制素。抑制蛋白广泛表达并存在于多个细胞区室中，包括线粒体、细胞核和质膜，并在线粒体、细胞质和细胞核之间穿梭。线粒体和细胞核的多个功能，包括细胞分化，抗增殖和形态发生。本文就近年来有关卵泡生成的研究进展作一综述。基于目前的研究结果，这些数据表明，这些分子通过作用于FSH信号转导通路的多个水平，在调节颗粒细胞对卵泡刺激素（FSH）的特异性反应中发挥重要作用。了解细胞内信号通路利用阿比汀调控卵泡发生的分子机制可能会导致克服生育障碍和抑制卵巢癌生长的策略的发展。
Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin (PHB) domain) found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans. Prohibitins are ubiquitously expressed and present in multiple cellular compartments including the mitochondria, nucleus, and the plasma membrane, and shuttles between the mitochondria, cytosol and nucleus. Multiple functions have been attributed to the mitochondrial and nuclear prohibitins, including cellular differentiation, anti-proliferation, and morphogenesis. In the present review, we focus on the recent developments in prohibitins research related to folliculogenesis. Based on current research findings, the data suggest that these molecules play important roles in modulating specific responses of granulose cells to follicle stimulating hormone (FSH) by acting at multiple levels of the FSH signal transduction pathway. Understanding the molecular mechanisms by which the intracellular signaling pathways utilize prohibitins in governing folliculogenesis is likely to result in development of strategies to overcome fertility disorders and suppress ovarian cancer growth.