Cross-talk between neurons and glia: highlights on soluble factors
Cross-talk between neurons and glia: highlights on soluble factors
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DOI：
10.1590/s0100-879x2001000500008
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发表时间：
2001-05-01
影响因子：
2.3
通讯作者：
Neto, VM
中科院分区：
文献类型：
--
作者：
Gomes, FCA;Spohr, TCLS;Neto, VM
神经系统的发育是由遗传程序代表的内在因素和以细胞与细胞相互作用为特征的表观遗传因素之间的平衡作用引导的，神经细胞可能在整个神经系统形态发生过程中形成这种相互作用。其中高度相关的是神经元-胶质细胞的相互作用。神经胶质细胞或神经元细胞分泌的几种可溶性因子与这些细胞之间的相互影响有关。在这篇综述中，我们将重点关注神经胶质细胞和神经元营养因子在神经系统发育中的作用的最新进展。我们认为，大脑的功能结构取决于神经元与神经胶质细胞的密切伙伴关系。
The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might form throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.