Prevention of pulmonary morbidity for patients with Duchenne muscular dystrophy
Prevention of pulmonary morbidity for patients with Duchenne muscular dystrophy
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DOI：
10.1378/chest.112.4.1024
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发表时间：
1997-10-01
期刊：
影响因子：
9.6
通讯作者：
Kim, H
中科院分区：
文献类型：
--
作者：
Bach, JR;Ishikawa, Y;Kim, H
研究目的：评价一种新的呼吸管理方案对杜氏肌营养不良（DMD）患者呼吸系统发病率和住院率的影响。设计：回顾性队列研究。方法：采用无创间歇正压通气（IPPV）预防或逆转氧合血红蛋白去饱和并根据需要辅助咳嗽的方案，比较24例DMD方案呼吸机使用者与22例非方案DMD气管切开IPPV使用者的住院率和住院天数。结果：22例常规治疗患者行气管切开术后平均住院时间为72.2±112天。这包括16.1±5.4天的经喉插管。24例方案患者平均住院时间为6.0+/-2.4天(p
Study objective: To evaluate the effects of a new respiratory management protocol on respiratory morbidity and hospitalization rates for patients with Duchenne muscular dystrophy (DMD).Design: A retrospective cohort study.Methods: Using a protocol in which oxyhemoglobin desaturation was prevented or reversed by the use of noninvasive intermittent positive pressure ventilation (IPPV) and assisted coughing as needed, the hospitalization rates and days for 24 protocol DMD ventilator users were compared with those of 22 nonprotocol DMD tracheostomy IPPV users.Results: The 22 conventionally managed patients were hospitalized a mean of 72.2+/-112 days when undergoing tracheostomy. This included a 16.1+/-5.4-day period of translaryngeal intubation. The 24 protocol patients were hospitalized a mean of 6.0+/-2.4 days (p