Characteristics of glucose metabolism in the visual cortex of amblyopes using positron-emission tomography and statistical parametric mapping
Characteristics of glucose metabolism in the visual cortex of amblyopes using positron-emission tomography and statistical parametric mapping
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DOI：
10.3928/0191-3913-20020101-05
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发表时间：
2002-01-01
影响因子：
1.2
通讯作者：
Yu, YS
中科院分区：
文献类型：
--
作者：
Choi, MY;Lee, DS;Yu, YS
背景：研究弱视对静息状态下视皮质糖代谢的影响，通过比较双侧枕叶低代谢像素数来检测同侧和对侧枕叶糖代谢的不对称性，并评价这种不对称性与眼科检查结果的相关性。方法：对11例弱视患者(屈光参差7例，斜视4例)和12例正常受试者在睁眼状态下进行F-18-脱氧葡萄糖正电子发射断层扫描(PET)和统计参数图检查。眼科检查包括立体视功能、对比敏感度、单眼视动性眼球震颤和视觉诱发电位。结果：无论是斜视性弱视还是屈光参差性弱视，弱视患者Brodmann区(BA)17，BAS 18/19，双侧颞叶下叶(BAS 37，BAS 20)和顶叶上叶(BA 7)的糖代谢均较正常人降低。枕叶低代谢象素的偏侧性指数与VEP潜伏期的不对称性密切相关(r=0.82，P<；0.05)。结论：PET葡萄糖代谢成像可提供弱视患者视皮质的功能图。
Background: The effects of amblyopia on the glucose metabolism in the visual cortex in the resting state are evaluated, the asymmetry of glucose metabolism in the ipsilateral and the contralateral occipital lobes was examined by comparing the number of hypometabolic pixels in both occipital lobes, and the correlation between this asymmetry and the results of the ophthalmologic tests was evaluated.Methods: Eleven amblyopes (7 anisometropic and 4 strabismic) and 12 normal subjects were studied with their eyes open, but without any further visual stimulus using F-18-fluorodeoxyglucose positron-emission tomography (PET) and statistical parametric mapping. Ophthalmologic tests including stereoacuity, contrast sensitivity function, monocular optokinetic nystagmus, and visual evoked potential (VEP) were measured. Results: Compared to normal subjects, glucose metabolism decreased in Brodmann area (BA) 17, BAs 18/19, both inferior temporal lobes (BAs 37 and 20), and the superior parietal lobe (BA 7) in amblyopic patients, regardless of strabismic or anisometropic amblyopia. The laterality index of the hypometabolic pixels in the occipital lobe closely correlated with the asymmetry in the latency time of VEP (r = 0.82, P < 0.05).Conclusion: These results suggest that PET imaging of glucose metabolism can provide a functional mapping of the visual cortex in human amblyopia.