HERPES-SIMPLEX VIRUS, TYPE-1 INVASION OF THE RABBIT AND MOUSE NERVOUS SYSTEMS REVEALED BY INSITU HYBRIDIZATION
HERPES-SIMPLEX VIRUS, TYPE-1 INVASION OF THE RABBIT AND MOUSE NERVOUS SYSTEMS REVEALED BY INSITU HYBRIDIZATION
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DOI：
10.1007/bf00692842
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发表时间：
1987-01-01
影响因子：
12.7
通讯作者：
SCHAEFER, DC
中科院分区：
文献类型：
--
作者：
STROOP, WG;SCHAEFER, DC
通过将 3H 标记的病毒体 DNA 探针应用于组织切片，我们之前已经确定了小鼠三叉神经节和中枢神经系统 (CNS) 感染急性期和潜伏期单纯疱疹病毒 (HSV) 的精确微观解剖位置。在本研究中，我们比较了小鼠和兔子支持三叉神经节和中枢神经系统神经元急性和潜伏感染的能力。我们发现HSV-1，F株，对小鼠和兔子的三叉神经节细胞产生急性和潜伏感染；然而，与小鼠神经元相比，兔子神经元中 HSV-1 RNA 的表达水平较低，并且兔子支持急性感染的神经元比小鼠少得多。对中枢神经系统内三叉神经系统的研究表明，HSV-1 在小鼠体内比在兔子体内更容易建立潜伏期。在急性感染的兔脑中观察到的组织病理学比在小鼠脑中的强度和分布范围要小。
Using a 3H-labelled virion DNA probe applied to tissue sections, we have previously identified the precise microscopic anatomical location of herpes simplex virus (HSV) during the acute and latent stages of infection of the mouse trigeminal ganglia and central nervous system (CNS). In the present investigation, we compared the mouse and the rabbit with respect to their ability to support acute and latent infections of trigeminal ganglionic and central nervous system neurons. We found that HSV-1, strain F, produced acute and latent infection of trigeminal ganglion cells in both mice and rabbits; however, lower levels of HSV-1 RNA were expressed in rabbit neurons as compared to mouse neurons, and many fewer neurons of the rabbit supported an acute infection than in the mouse. Studies of the trigeminal system within the CNS revealed that HSV-1 established latency more readily in the mouse than in the rabbit. The histopathology observed in acutely infected rabbit brain was less intense and less widespread than in mouse brain.