[Chromosome damage after occupational exposure to lead].
[Chromosome damage after occupational exposure to lead].
复制标题
[职业接触铅后的染色体损伤]。
DOI：
10.1055/s-0028-1108701
复制
发表时间：
1970
影响因子：
0.6
通讯作者：
E. Gebhart
中科院分区：
文献类型：
--
作者：
G. Schwanitz;G. Lehnert;E. Gebhart
该文件所附的英文摘要如下：-对一家铅氧化物工厂的工人进行了染色体分析和生化测试。所有受试者的血铅水平均明显升高。细胞学检查显示，与健康献血员对照组相比，接触铅氧化物的工人中继发性染色体畸变的有丝分裂比例增加。异常有丝分裂的百分比上升，增加尿中的β-氨基乙酰丙酸排泄。除染色体断裂外，还存在非特异性变化，如螺旋缺陷、染色体粘连和粉碎。四倍体比例和核分裂指数较对照组稍有增加。醋酸铅溶液（10-4至10-6摩尔）的体外实验证实了铅工人中发现的异常。值得注意的是，异常有丝分裂的比例在很大程度上与添加的醋酸铅浓度无关。鉴于铅的细胞遗传学效应，建议年轻的铅工人进行系列控制，最严格的评估标准。
The English summary appended to the paper is as follows: -Chromosome analyses and biochemical tests were performed on workers in a lead-oxide factory. All subjects had a markedly elevated blood-lead level. Cytological examination demonstrated an increased proportion of mitoses with secondary chromosomal aberrations in the workers exposed to lead-oxide, compared with a control group of healthy blood donors. The percentage of abnormal mitoses rose with an increasing (-aminolaevulinicacid excretion in the urine. In addition to chromosomal breaks there were also non-specific changes such as spiralizing defects, chromosomal adhesions and pulverization. The proportion of tetrapeloid mitoses and the mitoses index were slightly increased over those in the control group. In-vitro experiments with lead-acetate solution (10-4 to 10-6 mol) confirmed the abnormalities found in the lead workers. It was noticeable that the proportion of abnormal mitoses was largely independent of the added lead-acetate concentration. In view of the cytogenetic effect of lead it is recommended that young lead workers undergo serial controls with strictest criteria of assessment.