A taxonomy has been developed for outcomes in medical research to help improve knowledge discovery.
A taxonomy has been developed for outcomes in medical research to help improve knowledge discovery.
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DOI：
10.1016/j.jclinepi.2017.12.020
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发表时间：
2018-04
影响因子：
7.2
通讯作者：
Williamson PR
中科院分区：
文献类型：
--
作者：
Dodd S;Clarke M;Becker L;Mavergames C;Fish R;Williamson PR
人们越来越认识到，对临床试验中测量结果的选择没有给予足够的重视。由于不同研究中对结果的描述方式不明确且存在差异，缺乏标准化的结果分类系统会导致不一致。能够按结果进行分类将提高搜索来源的效率，例如临床试验注册、患者注册、Cochrane 系统评价数据库和核心结果集 (COS) 有效性试验中的核心结果测量 (COMET) 数据库，从而有助于知识发现。进行了文献综述以确定现有的结果分类系统，但没有一个系统足够全面或精细，无法对临床试验的所有潜在结果进行分类。开发了一种新的结果分类法，作为原理证明，从 COMET 数据库中所有已发布的 COS、选定的 Cochrane 综述和临床试验注册条目中提取的结果均使用该新系统进行了分类。将这种新分类法应用于 COMET 数据库中的 COS 表明，274/299 (92%) COS 至少包括一种生理结果，而只有 177 (59%) 包括至少一种影响衡量标准（整体生活质量或某种功能衡量标准），并且只有 105 (35%) 提到不良事件。该结果分类法将用于注释 COMET 数据库内 COS 中包含的结果，目前正在 Cochrane 关联数据项目内的 Cochrane 综述中进行试点。在试验和系统评价数据库和注册表中更广泛地实施这一标准分类法将进一步促进试验结果的高效搜索、报告和分类。
There is increasing recognition that insufficient attention has been paid to the choice of outcomes measured in clinical trials. The lack of a standardized outcome classification system results in inconsistencies due to ambiguity and variation in how outcomes are described across different studies. Being able to classify by outcome would increase efficiency in searching sources such as clinical trial registries, patient registries, the Cochrane Database of Systematic Reviews, and the Core Outcome Measures in Effectiveness Trials (COMET) database of core outcome sets (COS), thus aiding knowledge discovery. A literature review was carried out to determine existing outcome classification systems, none of which were sufficiently comprehensive or granular for classification of all potential outcomes from clinical trials. A new taxonomy for outcome classification was developed, and as proof of principle, outcomes extracted from all published COS in the COMET database, selected Cochrane reviews, and clinical trial registry entries were classified using this new system. Application of this new taxonomy to COS in the COMET database revealed that 274/299 (92%) COS include at least one physiological outcome, whereas only 177 (59%) include at least one measure of impact (global quality of life or some measure of functioning) and only 105 (35%) made reference to adverse events. This outcome taxonomy will be used to annotate outcomes included in COS within the COMET database and is currently being piloted for use in Cochrane Reviews within the Cochrane Linked Data Project. Wider implementation of this standard taxonomy in trial and systematic review databases and registries will further promote efficient searching, reporting, and classification of trial outcomes.
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影响因子：
15.8
作者：
McNair AG;Whistance RN;Forsythe RO;Macefield R;Rees J;Pullyblank AM;Avery KN;Brookes ST;Thomas MG;Sylvester PA;Russell A;Oliver A;Morton D;Kennedy R;Jayne DG;Huxtable R;Hackett R;Dutton SJ;Coleman MG;Card M;Brown J;Blazeby JM
通讯作者：
Blazeby JM
影响因子：
3.7
作者：
Gargon E;Gurung B;Medley N;Altman DG;Blazeby JM;Clarke M;Williamson PR
通讯作者：
Williamson PR
影响因子：
2.7
作者：
Mercer, Jeff;Penner, Murray;Younger, Alastair S. E.
通讯作者：
Younger, Alastair S. E.
影响因子：
14.2
作者：
Schmitt, Jochen;Langan, Sinead;Williams, Hywel C.
通讯作者：
Williams, Hywel C.
影响因子：
7.2
作者：
Kaufman, Jessica;Ryan, Rebecca;Hill, Sophie
通讯作者：
Hill, Sophie