The association between schizophrenia and cancer: a population-based mortality study
The association between schizophrenia and cancer: a population-based mortality study
复制标题
DOI：
10.1016/s0920-9964(01)00308-5
复制
发表时间：
2002-10-01
影响因子：
4.5
通讯作者：
Schorling, JB
中科院分区：
文献类型：
--
作者：
Cohen, ME;Dembling, B;Schorling, JB
背景：在本世纪的大部分时间里，人们一直在猜测被诊断为精神分裂症的人患癌症的几率会降低。目的：确定与一般人群相比，在控制已知风险和人口统计学因素的情况下，诊断为精神分裂症的患者中癌症史是否更常见。设计：我们使用了1986年全国死亡率追踪调查（NMFS），该调查从当年美国所有死亡人数中抽取了1%。数据来自死亡证明和生命最后一年的住院记录。通过采访死者家属和其他线人获得了更多健康和人口统计数据。我们比较了被诊断为精神分裂症的人（n = 130）和没有精神分裂症的人（n = 18，603），并使用logistic回归来确定被诊断为精神分裂症的人发生癌症的比值比。对死亡年龄进行了调整，以纠正被诊断患有精神分裂症的人平均比一般人群年轻10岁的事实。主要观察指标：医院记录或死亡证明上的癌症诊断。结果：精神分裂症患者患癌症的未校正比值比为0.62（95%可信区间（CI）0.40 - 0.96）。在控制了年龄、种族、性别、婚姻状况、教育、净资产、吸烟和死亡前一年的住院情况后，我们确定精神分裂症患者诊断癌症的比值比为0.59（95%CI 0.38-0.93）。结论：在这项基于人群的研究中，我们证明了被诊断患有精神分裂症的人患癌症的风险降低。(C)2002 Elsevier Science B. V.保留所有权利。
Background: For most of this century there has been speculation that persons diagnosed with schizophrenia have a reduced incidence of cancer. Objective: To determine if a history of cancer was more common in persons diagnosed with schizophrenia when compared with the general population, controlling for known risk and demographic factors. Design: We used the 1986 National Mortality Followback Survey (NMFS) which sampled 1% of all deaths in the US from that year. Data were obtained from death certificates and records of hospitalizations in the last year of life. Additional health and demographic data were obtained through interviews with decedents' families and other informants. We compared persons diagnosed with schizophrenia (n = 130) to individuals without schizophrenia (n = 18,603) and used logistic regression to determine the odds ratio for the occurrence of cancer in persons diagnosed with schizophrenia. Adjustment for age at death was done to correct for the fact that persons diagnosed with schizophrenia die on average 10 years younger than the general population. Main Outcome Measure: A diagnosis of cancer on a hospital record or the death certificate. Results: The unadjusted odds ratio for cancer among individuals with schizophrenia was 0.62 (95% confidence interval (CI) 0,40 - 0.96). After controlling for age, race, gender, marital status, education, net worth, smoking, and hospitalization in the year before death, we determined that the odds ratio for the diagnosis of cancer in persons with schizophrenia was 0.59 (95% Cl 0.38-0.93). Conclusion: In this population-based study, we demonstrated a reduced risk of cancer among persons diagnosed with schizophrenia. (C) 2002 Elsevier Science B.V. All rights reserved.