THROMBIN-INDUCED CALCIUM-INDEPENDENT DEGRANULATION OF HUMAN-NEUTROPHILS
THROMBIN-INDUCED CALCIUM-INDEPENDENT DEGRANULATION OF HUMAN-NEUTROPHILS
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DOI：
10.1007/bf00915829
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发表时间：
1986-12-01
期刊：
影响因子：
5.1
通讯作者：
RAZIN, E
中科院分区：
文献类型：
--
作者：
BARANES, D;MATZNER, J;RAZIN, E
凝血酶是一种高度特异性的凝血因子，它能迅速触发人中性粒细胞释放溶菌酶，而不同时激活5-脂氧合酶途径。这种激活不依赖于细胞外钙的存在。由于凝血酶还诱导从血小板和肥大细胞释放止血和炎性代谢物，因此认为其在炎症反应的放大中起重要作用。
Thrombin, a highly specific coagulation factor, can rapidly trigger lysozyme release from human neutrophils without concomitant acitvation of the 5-lipoxygenase pathway. This activation was not dependent on the presence of extracellular calcium. Since thrombin also induces the release of hemostatic and inflammatory metabolites from platelets and mast cells, it is proposed that it plays a significant role in amplification of the inflammatory response.