As time goes by: KRABs evolve to KAP endogenous retroelements.
As time goes by: KRABs evolve to KAP endogenous retroelements.
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DOI：
10.1016/j.devcel.2014.10.019
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发表时间：
2014-11-10
影响因子：
11.8
通讯作者：
Trono D
中科院分区：
文献类型：
--
作者：
Imbeault M;Trono D
近50%的人类基因组来自内源性逆转录因子，这些逆转录因子既是强大的进化力量，也是对其完整性的威胁。因此，这些基因入侵者从胚胎发育的最初几天起就受到转录抑制。雅各布斯等人在《自然》杂志上报道。通过鉴定含有KRAB的锌指蛋白家族中负责沉默人类L1和SVA特定亚集的两个成员，帮助我们了解这一过程的序列特异性。一缕曙光照亮了塑造移动元素和它们的宿主之间相互作用的进化力量。
Close to 50% of the human genome is derived from endogenous retroelements, which are both formidable evolutionary forces and threats to its integrity. Accordingly, these genetic invaders are subjected to transcriptional repression from the very first days of embryogenesis. Reporting in Nature, Jacobs et al. help us understand the sequence-specificity of this process, by identifying two members of the KRAB-containing zinc finger protein family responsible for silencing particular subsets of L1 and SVA in humans. A ray of light is shed on evolutionary forces that shape the interplay between mobile elements and their hosts.