Vimentin and epithelial-mesenchymal transition in human breast cancer - Observations in vitro and in vivo
Vimentin and epithelial-mesenchymal transition in human breast cancer - Observations in vitro and in vivo
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DOI：
10.1159/000101320
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Waltham, Mark
中科院分区：
文献类型：
--
作者：
Kokkinos, Maria I.;Wafai, Razan;Waltham, Mark
乳腺癌是一种在全世界妇女中高度流行的疾病。虽然这些肿瘤中某些蛋白质的表达用于预后和治疗选择，但仍然需要鉴定其他标志物。目前大量的文献主要基于细胞培养系统，表明乳腺癌进展的主要机制是由于肿瘤细胞失去上皮特征并获得间充质特性。这些事件被认为是非常相似的上皮-间充质转化（EMT）的过程中，已经很好地表征了胚胎发育。对于发育和推定的癌症EMT，细胞中间丝状态从连接到粘附连接和半桥粒的富含角蛋白的网络改变为连接到局灶性粘附的富含波形蛋白的网络。本文综述了波形蛋白在乳腺癌模型系统中表达的观察结果，并讨论了EMT在人类乳腺癌进展中的潜在作用，以及波形蛋白表达的预后作用。版权所有（c）2007 S. Karger AG，巴塞尔。
Breast cancer is a highly prevalent disease among women worldwide. While the expression of certain proteins within these tumours is used for prognosis and selection of therapies, there is a continuing need for additional markers to be identified. A considerable amount of current literature, based predominantly on cell culture systems, suggests that a major mechanism responsible for the progression of breast cancer is due to tumour cells losing their epithelial features and gaining mesenchymal properties. These events are proposed to be very similar to the epithelial-mesenchymal transition (EMT) process that has been well characterised in embryonic development. For the developmental and putative cancer EMT, the cell intermediate filament status changes from a keratin-rich network which connects to adherens junctions and hemidesmosomes, to a vimentin-rich network connecting to focal adhesions. This review summarises observations of vimentin expression in breast cancer model systems, and discusses the potential role of EMT in human breast cancer progression, and the prognostic usefulness of vimentin expression. Copyright (c) 2007 S. Karger AG, Basel.