Synergistic antifungal activity and reduced toxicity of liposomal amphotericin B combined with gramicidin S or NF.
Synergistic antifungal activity and reduced toxicity of liposomal amphotericin B combined with gramicidin S or NF.
复制标题
脂质体两性霉素 B 与短杆菌肽 S 或 NF 联合使用具有协同抗真菌活性并降低毒性。
DOI：
10.1128/aac.31.12.1978
复制
发表时间：
1987
影响因子：
4.9
通讯作者：
Lopez-Berestein,G
中科院分区：
文献类型：
--
作者：
Hopfer,RL;Mehta,R;Lopez-Berestein,G
Amphotericin B (AmpB) disrupts membrane integrity by binding to sterols in fungal and mammalian cell membranes. The gramicidins, which form pores in all membranes but exhibit poor antifungal activity, are too toxic to mammalian cells to be used systemically. This study demonstrated synergistic antifungal activity of free and liposomal forms of AmpB when combined with the free and liposomal forms of gramicidin S and gramicidin NF against five Candida strains. In vitro erythrocyte lysis was prevented by using the liposomal forms of all drugs tested alone or in combination. Presumably, AmpB increases accessibility of the fungal cell membrane to the gramicidins, while liposome encapsulation decreases the rate of transfer of the drugs to the mammalian cell membrane. Liposome encapsulation of inactive or toxic drugs, used in combination with liposomal AmpB, may give new life to drugs previously believed to be inactive or too toxic for therapeutic consideration.
