A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source
A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source
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DOI：
10.1088/0031-9155/54/8/005
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发表时间：
2009-04-21
影响因子：
3.5
通讯作者：
Zhou, O.
中科院分区：
文献类型：
--
作者：
Cao, G.;Lee, Y. Z.;Zhou, O.
Current commercial micro-CT scanners have the capability of imaging objects ex vivo with high spatial resolution, but performing in vivo micro-CT on free-breathing small animals is still challenging because their physiological motions are non-periodic and much faster than those of humans. In this paper, we present a prototype physiologically gated micro-computed tomography ( micro-CT) scanner based on a carbon nanotube field emission micro-focus x-ray source. The novel x-ray source allows x-ray pulses and imaging sequences to be readily synchronized and gated to non-periodic physiological signals from small animals. The system performance is evaluated using phantoms and sacrificed and anesthetized mice. Prospective respiratory-gated micro-CT images of anesthetized free-breathing mice were collected using this scanner at 50 ms temporal resolution and 6.2 lp mm(-1) at 10% system MTF. The high spatial and temporal resolutions of the micro-CT scanner make it well suited for high-resolution imaging of free-breathing small animals.
