HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN.
HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN.
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HBx 通过干扰 miR-181a 和 PTEN 之间的串扰来促进细胞增殖
DOI：
10.1038/srep40089
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发表时间：
2017-01-05
影响因子：
4.6
通讯作者：
Gong G
中科院分区：
文献类型：
--
作者：
Tian Y;Xiao X;Gong X;Peng F;Xu Y;Jiang Y;Gong G
Hepatitis B virus X protein (HBx) is involved in the initiation and progression of hepatocellular carcinoma (HCC). However, the mechanism is still needed to be elucidated. In this study, we explored the relationship between HBx and microRNA and their roles in hepato-carcinogenesis. Firstly, by global microarray-based microRNA profiling and qRT-PCR, we found miR-181a was strongly up-regulated in HepG2.2.15 cells (HBV positive) and pHBV1.3-expressing HepG2 cells, and HBx played a major role in it. Secondly, reduced PTEN protein expression in the presence of HBx was aslo mediated by miR-181a, and in the Luciferase reporter system, miR-181a inhibited the PTEN translation by binding the PTEN 3′-untranslated-region (UTR), and PTEN protein was decreased when epigenetic expression of miR-181a and rescued by knocking down miR-181a. Finally, HBx interrupted the balance between apoptosis and proliferation, which contributed to the development of hepatocellular carcinoma, was also related to the interaction of miR-181a and PTEN. Taken together, we presented here a novel cross-talk between miR-181a and PTEN which was raised by HBx, and this shined a new line in HBV-related hepato-carcinogenesis.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
--
作者：
Zhang, Xiangyang;Nie, Yuqiang;Li, Yuyuang
通讯作者：
Li, Yuyuang
乙型肝炎病毒X蛋白在体外下调恶性肝细胞中miR-16家族的表达
影响因子：
8.8
作者：
Wu, G.;Yu, F.;Xiao, Z.;Xu, K.;Xu, J.;Tang, W.;Wang, J.;Song, E.
通讯作者：
Song, E.
影响因子：
3.7
作者：
Peng F;Xiao X;Jiang Y;Luo K;Tian Y;Peng M;Zhang M;Xu Y;Gong G
通讯作者：
Gong G
影响因子：
13.5
作者：
Sze, Karen Man-Fong;Wong, Kris Lai-Ting;Ng, Irene Oi-Lin
通讯作者：
Ng, Irene Oi-Lin