[P1-504]: TACTILE PROCESSING IN DEMENTIA
[P1-504]: TACTILE PROCESSING IN DEMENTIA
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[P1-504]：痴呆症中的触觉处理
DOI：
10.1016/j.jalz.2017.06.520
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Bond R
中科院分区：
文献类型：
--
作者：
Bond R
背景“身体图式”指的是身体自我界限的内部模型，它允许我们将自己与整个世界区分开来。躯体图式缺陷是神经退行性疾病中躯体扭曲/妄想、异常人际互动(如情感触摸)和自我/非自我分化受损等主要症状的潜在机制。然而，痴呆症患者的身体图式处理仍然定义不清，部分原因是我们缺乏工具来充分描述它。我们在一组额颞性痴呆和阿尔茨海默病患者中使用触摸(正常身体模式的核心成分)范式来解决这个问题，参照健康的老年人。方法我们创建了一组新的触觉刺激，采样了一系列不同价态的有生命和无生命的纹理。参与者在利克特量表上对每个刺激的愉悦度进行评级，并在三种选择的强迫选择过程中从单词-图片序列中识别出来。结果患者组均表现出触觉加工障碍的症状特征，并伴有认知、情感和自主神经对触觉信息的分离编码。结论痴呆患者的触觉认知和反应能力的评估是可行的，这是一种分析不同痴呆症患者躯体图式加工缺陷的有前景的范式。
Background‘Body schema’refers to the internal model of physical self boundaries that allows us to differentiate ourselves from the world at large. Body schema deficits are a potential mechanism underpinning cardinal symptoms such as somatic distortions/delusions, abnormal interpersonal interactions (eg affective touch) and impaired self/non-self differentiation in neurodegenerative diseases. However, body schema processing remains poorly defined in patients with dementia, in part because we lack tools to characterise it adequately. We addressed this issue using the paradigm of touch (a core component of the normal body schema) in a cohort of patients with frontotemporal dementia and Alzheimer's disease, referenced to healthy older individuals.MethodsWe created a novel set of tactile stimuli sampling a range of animate and inanimate textures of variable valence. Participants rated the pleasantness of each stimulus on a Likert scale and identified it from a word-picture array in a three-alternative forced choice procedure. Autonomic arousal was assessed simultaneously using pupillometry.ResultsThe patient groups showed syndromic signatures of tactile processing impairment with evidence of dissociated cognitive, affective and autonomic coding of tactile information.ConclusionsIt is feasible to assess tactile cognition and reactivity in patients with dementia and this is a promising paradigm to dissect deficits of body schema processing in different dementia syndromes.