In situ dynamic control of neurite growth by femtosecond laser ablation of substrate patterns

In situ dynamic control of neurite growth by femtosecond laser ablation of substrate patterns
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通过飞秒激光烧蚀基底图案原位动态控制神经突生长

DOI:
10.1109/mhs.2016.7824186
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发表时间:
2016
期刊:
2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
影响因子:
--
通讯作者:
H. Masuhara
H. Masuhara
中科院分区:
--
文献类型:
--
作者:
K. Okano;Lin;Y. Hosokawa;H. Masuhara

文献摘要

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我们正在开发一种在培养基质上构建神经元网络的方法,用于研究神经元在信号处理和记忆方面的功能。在这里,我们展示了一种通过使用有限元对聚合物层进行二次激光烧蚀来引导神经突在基底上生长的方法。激光用于控制表面与神经元和神经突的亲和力。我们成功地实现了具有方向性的神经突生长。
We are developing a methodology to construct a neuron network on a culture substrate for studying neuronal functions on signal processing and memory. Here we show a method to guide neurite growth on a substrate by using fem to second laser ablation of polymer layer. The laser was used to control the affinity of the surface to neurons and neurites. We succeeded in neurite growth with directionality.