PRIMARY CILIARY DYSKINESIA IN THE DOG
PRIMARY CILIARY DYSKINESIA IN THE DOG
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DOI：
10.1111/j.1939-1676.1987.tb01989.x
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发表时间：
1987-04-01
影响因子：
2.6
通讯作者：
FARNUM, CE
中科院分区：
文献类型：
--
作者：
MORRISON, WB;WILSMAN, NJ;FARNUM, CE
电子显微镜被用来诊断原发性睫状体运动障碍在一窝英国指针狗和金毛猎犬。膜溶解，固定和戊二醛鞣酸负染色的技术确定异常构造的中央和B微管呼吸纤毛从狗原发性纤毛运动障碍。通常与原发性纤毛运动障碍相关的外动力蛋白臂缩短实际上代表了整个外动力蛋白臂结构的三个最外周组分的特定子集的缺失。
Electron microscopy was used to diagnose primary ciliary dyskinesia in a litter of English pointer dogs and in a golden retriever dog. A technique of membrane solubilization, fixation, and negative staining with glutaraldehyde tannic acid identified abnormally constructed central and B microtubules in respiratory cilia from dogs with primary ciliary dyskinesia. Shortened outer dynein arms commonly associated with primary ciliary dyskinesia actually represents the absence of a specific subset of the three most peripheral components of the whole outer dynein arm structure.