MicroRNA and Cancer: Tiny Molecules with Major Implications.
MicroRNA and Cancer: Tiny Molecules with Major Implications.
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microRNA和癌症：具有重大影响的微小分子。
DOI：
10.2174/138920208784139555
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发表时间：
2008-04
期刊：
影响因子：
2.6
通讯作者：
Sarkar FH
中科院分区：
文献类型：
--
作者：
Vandenboom Ii TG;Li Y;Philip PA;Sarkar FH
癌症目前是一个主要的公共卫生问题，因此，新兴的研究在确定其生物学中的主要参与者方面取得了重大进展。最近的一个感兴趣的主题涉及microRNA（miRNA），其是小的非编码RNA分子，其在转录后抑制基因表达。它们通过与靶信使RNA（mRNA）的3'非翻译区（3'UTR）结合来实现这一点，导致其降解或抑制翻译，这取决于互补碱基配对的程度。它们由RNA聚合酶II转录，并通过两个步骤形成成熟的miRNA，每个步骤由不同的核糖核酸酶III（RNaseIII）催化。跨物种的比较表明，miRNAs是进化保守的，并在广泛的正常生物过程中发挥重要作用。重要的是，异常的miRNA表达与人类疾病相关，特别是在癌症的发展中。最近的研究已经确定了miRNAs的靶点和功能，说明一些miRNAs在本质上是致癌的，而另一些则显示出肿瘤抑制活性。miRNA还被表征为在临床竞技场中具有高潜力，因此，已经成为开发用于癌症治疗的靶标。不仅已经表明miRNA表达谱可以证明是癌症诊断和预后标志物，各种基于miRNA的疗法也显示出希望。预计进一步的研究将阐明使用miRNAs作为临床药物对抗癌症和其他慢性疾病的益处。
Cancer is currently a major public health problem and, as such, emerging research is making significant progress in identifying major players in its biology. One recent topic of interest involves microRNAs (miRNAs) which are small, non-coding RNA molecules that inhibit gene expression post-transcriptionally. They accomplish this by binding to the 3’ untranslated region (3’UTR) of target messengerRNA (mRNA), resulting in either their degradation or inhibition of translation, depending on the degree of complementary base pairing. They are transcribed by RNA polymerase II and are formed into mature miRNAs via two steps, each catalyzed by a different ribonuclease III (RNaseIII). Cross-species comparisons demonstrate that miRNAs are evolutionarily conserved and play important roles in a wide array of normal biological processes. Importantly, aberrant miRNA expression is correlated with human disease, especially in the development of cancer. Recent research has identified targets and functions of miRNAs, illustrating that some are oncogenic in nature while others show tumor suppressor activity. The miRNAs have also been characterized as having high potential in the clinical arena and, as such, have been a target for exploitation toward cancer therapy. Not only has it been shown that miRNA expression profiles may prove useful as diagnostic and prognostic markers in cancer, various miRNA-based therapies show promise as well. It is anticipated that further research will elucidate the benefits of using miRNAs as clinical agents in the battle against cancer and other chronic diseases.
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影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
14.9
作者：
Griffiths-Jones S;Grocock RJ;van Dongen S;Bateman A;Enright AJ
通讯作者：
Enright AJ
DOI：
10.1073/pnas.0703942104
发表时间：
2007-10-09
影响因子：
11.1
作者：
Gironella, Meritxell;Seux, Mylene;Dusetti, Nelson J.
通讯作者：
Dusetti, Nelson J.
影响因子：
64.8
作者：
Denli, AM;Tops, BBJ;Hannon, GJ
通讯作者：
Hannon, GJ
影响因子：
10.5
作者：
Han, JJ;Lee, Y;Kim, VN
通讯作者：
Kim, VN