Carbohydrate moieties as vaccine candidates
Carbohydrate moieties as vaccine candidates
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DOI：
10.1086/432582
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发表时间：
2005-09-01
影响因子：
11.8
通讯作者：
Taylor, CE
中科院分区：
文献类型：
--
作者：
Lucas, AH;Apicella, MA;Taylor, CE
碳水化合物表位或糖表位在结构上是多样的，存在于各种化学环境中，并且存在于体内细胞表面和病原体表面上。这些不同的结构和呈现模式影响它们如何被身体感知和处理，并决定针对它们的免疫应答的结果。本文综述了碳水化合物免疫的机制，重点是已经或正在开发的碳水化合物疫苗，以保护对封装的细菌病原体。我们讨论了碳水化合物免疫的细胞基础，新发现的糖表位加工途径和识别能力，以及正在开发的合成和微阵列技术，这将允许新的实验方法来开发碳水化合物疫苗和探索免疫系统与自身和非自身聚糖的相互作用。
Carbohydrate epitopes or glycotopes are structurally diverse, occur in a variety of chemical contexts, and are present on the surfaces of cells in the body and on the surfaces of pathogens. These various structures and modes of presentation affect how they are perceived and processed by the body and dictate the outcome of the immune response directed against them. This review focuses on mechanisms of carbohydrate immunity, with an emphasis on carbohydrate vaccines that have been or are being developed for protection against encapsulated bacterial pathogens. We discuss the cellular basis of carbohydrate immunity, newly identified glycotope processing pathways and recognition capabilities, and the synthetic and microarray technologies that are being developed that will permit new experimental approaches to carbohydrate vaccine development and the exploration of the interaction of the immune system with self and nonself glycans.