Extracellular matrix degradation and remodeling in development and disease.
Extracellular matrix degradation and remodeling in development and disease.
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DOI：
10.1101/cshperspect.a005058
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发表时间：
2011-12-01
影响因子：
7.2
通讯作者：
Werb Z
中科院分区：
文献类型：
--
作者：
Lu P;Takai K;Weaver VM;Werb Z
细胞外基质（ECM）具有多种功能，是细胞微环境的主要组成部分。ECM是高度动态的结构，不断经历重塑过程，其中ECM组分沉积、降解或以其他方式修饰。ECM动力学在组织结构的重建过程中是必不可少的。ECM重塑是一种重要的机制，由此可以调节细胞分化，包括诸如建立和维持干细胞小生境、分支形态发生、血管生成、骨重塑和伤口修复的过程。相反，异常ECM动力学导致失调的细胞增殖和侵袭、细胞死亡失败和细胞分化丧失，导致先天性缺陷和病理过程，包括组织纤维化和癌症。因此，了解ECM重塑及其调节的机制对于开发新的疾病治疗干预措施以及组织工程和再生医学的新策略至关重要。
The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture. ECM remodeling is an important mechanism whereby cell differentiation can be regulated, including processes such as the establishment and maintenance of stem cell niches, branching morphogenesis, angiogenesis, bone remodeling, and wound repair. In contrast, abnormal ECM dynamics lead to deregulated cell proliferation and invasion, failure of cell death, and loss of cell differentiation, resulting in congenital defects and pathological processes including tissue fibrosis and cancer. Understanding the mechanisms of ECM remodeling and its regulation, therefore, is essential for developing new therapeutic interventions for diseases and novel strategies for tissue engineering and regenerative medicine.