Ramping ensemble activity in dorsal anterior cingulate neurons during persistent commitment to a decision
Ramping ensemble activity in dorsal anterior cingulate neurons during persistent commitment to a decision
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DOI：
10.1152/jn.00711.2015
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发表时间：
2015-10-01
影响因子：
2.5
通讯作者：
Hayden, Benjamin Y.
中科院分区：
文献类型：
--
作者：
Blanchard, Tommy C.;Strait, Caleb E.;Hayden, Benjamin Y.
我们经常需要做出选择来实现我们的目标；然而，让我们有动力追求延迟目标的神经过程仍然模糊。我们检查了猕猴背侧前扣带皮层（dACC）神经元的整体反应，该区域以前与自我控制和坚持有关，在一项需要做出选择才能获得奖励的任务中。收到奖励后，dACC 神经元以特有的整体放电率模式发出奖励金额信号；在等待奖励的延迟期间，群体活动顺利并逐渐变得类似于奖励后模式。在风险试验的子集中，其中预期奖励的确定性为 50%，整体活动逐渐演化为与预期奖励（而不是预期损失）相关的模式，然后，在损失试验中，呈现与胜利相关的形式反相关的倒置形式。这些发现丰富了我们对 dACC 奖励处理的了解，并可能对我们对坚持和自我控制的理解产生更广泛的影响。
We frequently need to commit to a choice to achieve our goals; however, the neural processes that keep us motivated in pursuit of delayed goals remain obscure. We examined ensemble responses of neurons in macaque dorsal anterior cingulate cortex (dACC), an area previously implicated in self-control and persistence, in a task that requires commitment to a choice to obtain a reward. After reward receipt, dACC neurons signaled reward amount with characteristic ensemble firing rate patterns; during the delay in anticipation of the reward, ensemble activity smoothly and gradually came to resemble the postreward pattern. On the subset of risky trials, in which a reward was anticipated with 50% certainty, ramping ensemble activity evolved to the pattern associated with the anticipated reward (and not with the anticipated loss) and then, on loss trials, took on an inverted form anticorrelated with the form associated with a win. These findings enrich our knowledge of reward processing in dACC and may have broader implications for our understanding of persistence and self-control.