Inhibition of rat parotid and submandibular gland functions by ofloxacin, a fluoroquinolone antibiotic
Inhibition of rat parotid and submandibular gland functions by ofloxacin, a fluoroquinolone antibiotic
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DOI：
10.1046/j.1472-8206.2001.00041.x
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发表时间：
2001-10-01
影响因子：
2.9
通讯作者：
Isazadeh, Z
中科院分区：
文献类型：
--
作者：
Abdollahi, M;Isazadeh, Z
虽然氟喹诺酮类药物广泛用于治疗各种感染性疾病，但其对唾液腺功能的不良影响尚未引起足够的重视。在本研究中，通过急性实验检查了氧氟沙星（一种氟喹诺酮类抗生素）对大鼠腮腺和颌下腺功能的影响。氧氟沙星 (OFLX) 以不同剂量（20、40 和 80 mg/kg）腹腔内给药。使用解剖显微镜在麻醉下通过微型聚乙烯管在口内收集纯腮腺和下颌下唾液。所有剂量的 OFLX（20、40、80 mg/kg，P < 0.01）均降低腮腺唾液中的流速、淀粉酶活性、总蛋白和钙浓度。在腮腺唾液中，钠和钾的含量分别随着20和40 mg/kg（P < 0.01）和20、40、80 mg/kg（P < 0.01）的剂量而增加。在下颌下唾液中，所有剂量 20、40、80 mg/kg 均显着降低流速、总蛋白和钙浓度，P < 0.01）。下颌下唾液中钠和钾的浓度也随着剂量为80 mg/kg而增加（P < 0.05）。结论是氧氟沙星抑制大鼠唾液腺功能，这可能在人类中观察到作为副作用。氟喹诺酮类药物改变细胞内 cAMP 和钙水平的特性及其抑制腺泡细胞 DNA、RNA 和蛋白质合成的能力可能是观察到的变化的可能原因。
While fluoroquinolones are widely used in the treatment of various infectious disease, not enough attention has been paid to their adverse effects on salivary glands functions. In the present study, the effects of ofloxacin, a fluoroquinolone antibiotic, on rat parotid and submandibular gland functions, were examined in an acute experiment. Ofloxacin (OFLX) was administered intraperitoneally at various doses (20, 40, and 80 mg/kg). Pure parotid and submandibular saliva were collected intraorally by microployethylene tubes under anaesthesia using a dissecting microscope. Flow rate, amylase activity, total protein, and calcium concentrations were reduced by all doses of OFLX (20, 40, 80 mg/kg, P < 0.01) in parotid saliva. In parotid saliva, sodium and potassium were increased by doses of 20 and 40 mg/kg (P < 0.01) and 20, 40, 80 mg/kg (P < 0.01) respectively. In submandibular saliva, flow rate, total protein and calcium concentrations were significantly reduced by all doses 20, 40, 80 mg/kg, P < 0.01). Sodium and potassium concentrations were also increased by a dose of 80 mg/kg, (P < 0.05) in submandibular saliva.It is concluded that ofloxacin inhibits rat salivary gland functions, which might be observed as a side-effect in humans. Properties of fluoroquinolones to alter intracellular cAMP and calcium levels and their ability to suppress DNA, RNA and protein synthesis of acinar cells might be possible reasons for the observed changes.