SUPPRESSION OF SUBGINGIVAL ACTINOBACILLUS-ACTINOMYCETEMCOMITANS IN LOCALIZED JUVENILE PERIODONTITIS BY SYSTEMIC TETRACYCLINE
SUPPRESSION OF SUBGINGIVAL ACTINOBACILLUS-ACTINOMYCETEMCOMITANS IN LOCALIZED JUVENILE PERIODONTITIS BY SYSTEMIC TETRACYCLINE
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DOI：
10.1111/j.1600-051x.1993.tb00379.x
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发表时间：
1993-07-01
影响因子：
6.7
通讯作者：
ZAMBON, JJ
中科院分区：
文献类型：
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作者：
CHRISTERSSON, LA;ZAMBON, JJ
本研究评估了全身性抗菌治疗对伴放线放线杆菌感染的青少年牙周病的临床和微生物学影响。本研究涉及6名13-18岁的局限性青少年牙周炎患者，他们携带高数量的A。龈下菌斑样本中的伴放线菌。通过选择性培养对牙周病变进行微生物监测，并在基线前3个月和治疗后3、6、12和24个月对牙周袋深度和牙周附着水平进行临床评估。处方盐酸四环素（250 mg/QID），直至龈下A后1周。伴放线菌不再可检测或最多持续8周。在治疗前3个月内，囊袋深度保持不变，然后在治疗后12个月从平均7.1 mm显著降低至5.1 mm（p = 0.02）。临床附着水平的平均变化是基线和12个月之间增加1.4 mm（p = 0.02）。6例患者中3例仍有A.抗生素治疗8周后，4名受试者感染了伴放线菌，12个月后，4名受试者感染了伴放线菌。A的数量。伴放线菌在大部分病变中仍被抑制。A的平均数量之间有很强的相关性。在任何给定的时间点，牙周袋中的放线菌共生体和探测附着水平的平均变化。对于来自所有时间点的22个可用比较，龈下A之间存在强相关性（r = 0.68）。放线菌共生菌和探测附着水平的变化。9个（89%;灵敏度）具有“疾病”（探测附着水平增加< 1.5 mm）的个体患者时间间隔中的8个被测试为阳性（大于或等于100 CFU），而13个（69%;特异性）具有“无疾病”（探测附着水平增加大于或等于1.5 mm）的个体患者时间间隔中的9个被测试为A。伴放线菌阴性（< 100 CFU）（p = 0.007）。
The current study assessed the clinical and microbiological effects of systemic antimicrobial therapy alone in Actinobacillus actinomycetemcomitans-infected adolescents with periodontal disease. The study involved 6 localized juvenile periodontitis patients 13-18 years of age, who harbored high numbers of A. actinomycetemcomitans in subgingival plaque samples. The periodontal lesions were microbiologically monitored by selective culture, and clinically assessed for probing pocket depth and periodontal attachment level 3 months prior to baseline, and at 3, 6, 12, and 24 months posttreatment. Tetracycline-HCl (250 mg/QID) was prescribed until 1 week after subgingival A. actinomycetemcomitans was no longer detectable or for a maximum of 8 weeks. During 3 months prior to treatment, pocket depth was unchanged, and was then significantly reduced from an average of 7.1 mm to 5.1 mm 12 months after treatment (p = 0.02). The mean change in clinical attachment level was a gain of 1.4 mm between baseline and 12 months (p = 0.02). 3 of the 6 patients were still infected with A. actinomycetemcomitans after 8 weeks of antibiotic therapy and 4 subjects were infected at 12 months. Numbers of A. actinomycetemcomitans were still suppressed in most lesions. There was a strong association between mean numbers of A. actinomycetemcomitans in periodontal pockets and mean change in probing attachment level at any given time point. For 22 available comparisons, derived from all time points, there was a strong association (r = 0.68) between subgingival A. actinomycetemcomitans and change in probing attachment level. 8 of 9 (89%; sensitivity) individual patient time intervals with ''disease'' (< 1.5 mm gain in probing attachment level) were tested positive (greater-than-or-equal-to 100 CFU), whereas 9 of 13 (69%; specificity) individual patient time intervals with ''no disease'' (greater-than-or-equal-to 1.5 mm gain in probing attachment level) were A. actinomycetemcomitans negative (< 100 CFU) (p = 0.007).