Amino group binding peptide aptamers with double disulphide-bridged loops selected by in vitro selection using cDNA display
Amino group binding peptide aptamers with double disulphide-bridged loops selected by in vitro selection using cDNA display
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DOI：
10.1039/c4cc00799a
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Nemoto, Naoto
中科院分区：
文献类型：
--
作者：
Mochizuki, Yuki;Nishigaki, Koichi;Nemoto, Naoto
采用cDNA展示法体外筛选固相上特异性结合氨基酸的肽适体。所鉴定的肽具有独特的结构，包含两个具有二硫键的环状环和一个连接区域，这是分子识别必不可少的。
Peptide aptamers that specifically bind to the amino group on a solid-phase were screened by in vitro selection using the cDNA display method. The identified peptides have a unique structure containing two cyclic loops with disulphide bonds and a linkage region, which were indispensable for molecular recognition.