Age-related changes in plasma and tissue fatty acid composition in Fischer 344 rats.
Age-related changes in plasma and tissue fatty acid composition in Fischer 344 rats.
复制标题
Fischer 344 大鼠血浆和组织脂肪酸组成的年龄相关变化。
DOI：
10.1080/15216549800204672
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Nguyen,H
中科院分区：
文献类型：
--
作者：
Engler,MM;Engler,MB;Nguyen,H
年龄增长与冠状动脉疾病风险增加有关。脂肪酸代谢的变化影响重要的细胞膜特性和功能，这可能有助于血管衰老的病理生理学。本研究旨在研究衰老对4、15和24月龄Fischer 344大鼠（衰老动物模型）血浆、肝脏、主动脉和肾动脉脂肪酸组成的影响。随着年龄的增长，血浆、主动脉和肾动脉中的总多不饱和脂肪酸（PUFA）水平增加。肝脏脂肪酸谱的主要变化是18：2n6和18：3n3水平升高，20：3n6和20：5n3水平降低。结果表明，随着年龄的增长，血浆、肝脏和血管中的n6和n3 PUFA水平发生显著变化。脂肪酸组成的改变可能是与衰老相关的血管变化的发病机制。
Advancing age is associated with increased risk of coronary artery disease. Changes in fatty acid metabolism affect important cellular membrane properties and functions which may contribute to the vascular pathophysiology of aging. This study was designed to investigate the effects of aging on the fatty acid composition of the plasma, liver, aorta, and renal artery in 4‐, 15‐, and 24‐month old Fischer 344 rats, an animal model for aging. With aging, the levels of total polyunsaturated fatty acids (PUFA) increased in the plasma, aorta, and renal artery. The major changes in the liver fatty acid profile were increases in the levels of 18:2n6 and 18:3n3 and a decrease in the levels of 20:3n6 and 20:5n3. The results indicate that significant shifts occur in the levels of n6 and n3 PUFA in the plasma, liver, and vasculature with aging. The alterations in the fatty acid composition may be a pathogenetic mechanism of the vascular changes associated with aging.