Vitamin D and renal calcium transport.
Vitamin D and renal calcium transport.
复制标题
维生素 D 和肾钙转运。
DOI：
10.1097/00041552-199407000-00008
复制
发表时间：
1994
影响因子：
3.2
通讯作者：
Kumar,R
中科院分区：
文献类型：
--
作者：
Johnson,JA;Kumar,R
The kidney plays an important role in maintaining calcium balance in plasma and extracellular fluid. 1, 25 Dihydroxy vitamin D3, which regulates intestinal calcium absorption, bone calcium resorption, and renal calcium reabsorption, is synthesized in the renal proximal tubules. Vitamin D-dependent calcium reabsorption from urine occurs in renal distal tubules. New information, obtained from both intestinal and kidney cells, enables us to propose a model of the mechanism of vitamin D-dependent calcium transport in renal distal tubule cells. This model involves several vitamin D-regulated processes and proteins. Briefly, 1, 25 dihydroxy vitamin D3 stimulates calcium uptake at the distal tubule luminal membrane. A cytosolic vitamin D-dependent calcium binding protein (calbindin-D) sequesters calcium, which allows more calcium to enter the cell and more efficient diffusion of calcium across the cell. The ATP-dependent plasma membrane Ca2+ pump in the basolateral membrane pumps calcium out of the distal tubule cells into plasma
