Influence of in Vitro Degradation of a Biodegradable Nanocomposite on Its Shape Memory Effect
Influence of in Vitro Degradation of a Biodegradable Nanocomposite on Its Shape Memory Effect
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可生物降解纳米复合材料体外降解对其形状记忆效应的影响
DOI：
10.1021/jp9022986
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发表时间：
2009-09
影响因子：
3.7
通讯作者：
Zhou, Shaobing
中科院分区：
文献类型：
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作者：
Xiao, Yu;Yu, Xiongjun;Guo, Tao;Zheng, Xiaotong;Zhou, Shaobing
研究了交联聚己内酯（c-PCL）/Fe 3 O 4纳米粒子形状记忆复合材料的制备及其体外降解性能。从聚合物的力学性能、质量和分子量的下降、磷酸盐缓冲液（PBS）pH值的变化以及复合材料的形态变化等方面评价了复合材料的降解行为。凝胶分数和分子量分析结果表明，PBS降解介质对c-PCL的化学网络结构有一定的破坏作用，但对c-PCL的线性分子构型影响较小。预期的是，体外降解对形状记忆效应的负面影响已经被观察到。通过测试这些与降解相关的物理化学性质，分析了其降解行为，并进一步解释了形状记忆恢复的变化。并根据降解结果对c-PCL的降解机理进行了初步探讨。
Preparation and in vitro degradation of shape memory nanocomposites consisting of cross-linked poly(e-caprolactone) (c-PCL) and Fe3O4 nanoparticles were investigated in this study. The degradation behaviors were evaluated from the decrease of mechanical property, weight, and molecular weight of polymer, the change of pH value of phosphate-buffered saline (PBS), and morphological changes in composites. The results from gel fraction and molecular weight analysis indicated some damages were brought to chemical networks of c-PCL, but its linear molecule configuration received less impact from PBS degradation medium. Expectedly, the negative influence of the in vitro degradation on shape memory effect had been observed. All these physical and chemical properties related to degradation had been tested to analyze degradation behaviors, which were further used to explain the changes in shape memory recovery. Furthermore, on the basis of the degradation results, the mechanism of c-PCL degradation was also put forw...