CLINICAL AND HEMODYNAMIC-EFFECTS OF DIAZOXIDE IN PRIMARY PULMONARY-HYPERTENSION
CLINICAL AND HEMODYNAMIC-EFFECTS OF DIAZOXIDE IN PRIMARY PULMONARY-HYPERTENSION
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DOI：
10.1136/thx.35.4.269
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发表时间：
1980-01-01
期刊：
影响因子：
10
通讯作者：
DENISON, D
中科院分区：
文献类型：
--
作者：
HONEY, M;COTTER, L;DENISON, D
对9例高血压性肺动脉高压患者行二氮嗪肺动脉内注射治疗。肺动脉压无明显变化，仅2例患者的肺动脉压下降超过10 mm Hg。由于肺血管阻力下降(下降4-17个单位)，所有患者的肺血流量都增加了。所有患者的全身血管阻力如预期般下降。7例患者口服二氮嗪，其中2例在继续治疗(400-600 mg/d)的同时，临床症状持续改善。患者(5例)因恶心和恶心(2例)、需要大剂量利尿剂的外周水肿(4例)、糖尿病(3例)和体位性低血压(1例)而无法耐受该药。在仍在接受治疗的2名患者中，多毛症是令人困扰的。二氮嗪在一些原发性肺动脉高压患者的治疗中可能是有用的，但其使用受到副作用频率的限制。检查其他有效的血管扩张剂可能是值得的。
Diazoxide was injected into the pulmonary artery in 9 patients with primary pulmonary hypertension. There was no significant change in pulmonary artery pressure, which fell by more than 10 mm Hg in only 2 patients. The pulmonary blood flow increased in all patients as a result of a fall in pulmonary vascular resistance (by 4-17 units). Systematic vascular resistance fell as expected in all patients. Oral diazoxide was given to 7 patients, 2 of whom showed sustained clinical improvement while remaining on treatment (400-600 mg daily). Patients (5) were unable to tolerate the drug, because of nausea and sickness (2), peripheral edema requiring large doses of diuretics (4), diabetes (3) and postural hypotension (1). Hirsutism was troublesome in the 2 patients remaining on treatment. Diazoxide may be useful in the management of some patients with primary pulmonary hypertension, but its use is limited by the frequency of side effects. Examination of other potent vasodilators may be worthwhile.