Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discounting
Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discounting
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DOI：
10.1016/j.neuroimage.2010.08.067
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发表时间：
2011-01-15
期刊：
影响因子：
5.7
通讯作者：
Rubia, Katya
中科院分区：
文献类型：
--
作者：
Christakou, Anastasia;Brammer, Mick;Rubia, Katya
时间折扣（TD）随着年龄的增长而成熟，以及其他增加冲动控制的标志，以及连贯的自我调节行为。贴现范式量化的能力，以避免偏好的即时奖励，有利于延迟，更大的奖励。因此，他们测量的是时间预见和延迟满足的能力，这些功能在成年后会慢慢发展。我们研究了神经成熟，伴随着先前观察到的年龄相关的行为变化，从青春期早期到成年中期的折扣。我们使用功能性磁共振成像的一个假设的折扣任务与货币奖励延迟在一周到一年的范围。我们发现，与年龄相关的选择冲动的减少与腹内侧前额叶皮层（vmPFC），前扣带皮层（ACC），腹侧纹状体（VS），颞下回，后顶叶皮层的激活变化。边缘系统额纹状体激活的变化与年龄依赖性冲动选择的减少特别相关，作为更广泛的大脑区域网络的一部分，显示出与年龄相关的激活变化，包括背外侧PFC，下顶叶皮质和皮质下区域。功能连接的成熟模式包括在选择延迟选项时腹内侧和背外侧PFC、顶叶和岛叶皮质之间的激活耦合加强，以及在选择即时选项时vmPFC和VS之间的激活耦合加强。我们的结论是，成熟机制内边缘额叶纹状体电路的基础上观察到的青春期后减少冲动的选择随着年龄的增长，这种效果是依赖于增加激活的一致性与折扣行为和跨时间的决策网络内的区域。(C)2010年爱思唯尔公司All rights reserved.
Temporal discounting (TD) matures with age, alongside other markers of increased impulse control, and coherent, self-regulated behaviour. Discounting paradigms quantify the ability to refrain from preference of immediate rewards, in favour of delayed, larger rewards. As such, they measure temporal foresight and the ability to delay gratification, functions that develop slowly into adulthood. We investigated the neural maturation that accompanies the previously observed age-related behavioural changes in discounting, from early adolescence into mid-adulthood. We used functional magnetic resonance imaging of a hypothetical discounting task with monetary rewards delayed in the week to year range. We show that age-related reductions in choice impulsivity were associated with changes in activation in ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), ventral striatum (VS), insula, inferior temporal gyrus, and posterior parietal cortex. Limbic frontostriatal activation changes were specifically associated with age-dependent reductions in impulsive choice, as part of a more extensive network of brain areas showing age-related changes in activation, including dorsolateral PFC, inferior parietal cortex, and subcortical areas. The maturational pattern of functional connectivity included strengthening in activation coupling between ventromedial and dorsolateral PFC, parietal and insular cortices during selection of delayed alternatives, and between vmPFC and VS during selection of immediate alternatives. We conclude that maturational mechanisms within limbic frontostriatal circuitry underlie the observed post-pubertal reductions in impulsive choice with increasing age, and that this effect is dependent on increased activation coherence within a network of areas associated with discounting behaviour and inter-temporal decision-making. (C) 2010 Elsevier Inc. All rights reserved.