Regulation of Organ Growth by Morphogen Gradients
Regulation of Organ Growth by Morphogen Gradients
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DOI：
10.1101/cshperspect.a001669
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发表时间：
2010-01-01
影响因子：
7.2
通讯作者：
Basler, Konrad
中科院分区：
文献类型：
--
作者：
Schwank, Gerald;Basler, Konrad
形态发生梯度在器官形态和器官生长中起着重要作用。不同于它们在图案形成中的作用，它们在调节器官生长和大小方面的功能知之甚少。形态形成梯度如何以及为什么发挥其有丝分裂作用，在发育中的器官中产生均匀的增殖，以及形态形成因子通过什么方式影响器官的最终大小？果蝇翅膀影像盘的十足截瘫梯度（Dpp）已成为研究器官生长的合适且成熟的系统。在这里，我们回顾了模型和最近的发现，试图解决Dpp形态原如何促进细胞的均匀增殖，以及它如何调节翼盘的最终大小。
Morphogen gradients play a fundamental role in organ patterning and organ growth. Unlike their role in patterning, their function in regulating the growth and the size of organs is poorly understood. How and why do morphogen gradients exert their mitogenic effects to generate uniform proliferation in developing organs, and by what means can morphogens impinge on the final size of organs? The decapentaplegic (Dpp) gradient in the Drosophila wing imaginal disc has emerged as a suitable and established system to study organ growth. Here, we review models and recent findings that attempt to address how the Dpp morphogen contributes to uniform proliferation of cells, and how it may regulate the final size of wing discs.