The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis.
The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis.
复制标题
DOI：
10.1155/2016/3276383
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Ostatnikova D
中科院分区：
文献类型：
--
作者：
Bakos J;Zatkova M;Bacova Z;Ostatnikova D
下丘脑是神经祖细胞的来源，在大脑发育过程中产生不同的特化和分化细胞群。下丘脑中新形成的神经元可以合成和释放各种神经肽。虽然术语神经肽最近经历了重新定义，但小尺寸下丘脑神经肽仍然是介导大脑发育的短期和长期影响的主要信号分子。它们是神经突生长和神经回路形成的重要因素。有证据表明，新生成的下丘脑神经元可能参与代谢、能量平衡、体重和社会行为的调节。在这里，我们回顾了下丘脑神经肽在成人神经发生和神经胚胎发生中的作用的最新数据，特别强调了食物摄入和社会行为相关脑回路的发展。
The hypothalamus is a source of neural progenitor cells which give rise to different populations of specialized and differentiated cells during brain development. Newly formed neurons in the hypothalamus can synthesize and release various neuropeptides. Although term neuropeptide recently undergoes redefinition, small-size hypothalamic neuropeptides remain major signaling molecules mediating short- and long-term effects on brain development. They represent important factors in neurite growth and formation of neural circuits. There is evidence suggesting that the newly generated hypothalamic neurons may be involved in regulation of metabolism, energy balance, body weight, and social behavior as well. Here we review recent data on the role of hypothalamic neuropeptides in adult neurogenesis and neuritogenesis with special emphasis on the development of food intake and social behavior related brain circuits.