Low Normalized Grip Strength is a Biomarker for Cardiometabolic Disease and Physical Disabilities Among US and Chinese Adults
Low Normalized Grip Strength is a Biomarker for Cardiometabolic Disease and Physical Disabilities Among US and Chinese Adults
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DOI：
10.1093/gerona/glx031
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发表时间：
2017-11-01
影响因子：
5.1
通讯作者：
Zhao, Yaohui
中科院分区：
文献类型：
--
作者：
Peterson, Mark D.;Duchowny, Kate;Zhao, Yaohui
背景：证据强调了肌肉力量作为老年人群健康和功能保护因素的重要性。本研究的目的是在美国调查低标准化握力（NGS）作为心脏代谢疾病和身体残疾的生物标志物的程度。S.方法：对美国和中国的中老年人进行问卷调查。S.纳入了2011-2012年和2013-2014年全国健康与营养调查联合调查（n = 4，544）和2011年中国健康与退休纵向研究（n = 6，030）。使用握把测力计评估力量，并根据体重进行标准化。在控制年龄、性别和社会人口学特征的同时，采用加权logistic回归模型评估NGS与糖尿病、高血糖、高胆固醇血症、低HDL胆固醇、高血压和身体残疾状态之间的关联。（95%置信区间[ CI]：1.42-1.56）和1.17（95% CI：1.11-1.23）糖尿病的几率; 1.46（95% CI：1.39-1.53）和1.11（95% CI：1.07-1.15）高血糖的几率; a 1.15（95% CI：1.07-1.25）和1.11（95% CI：1.08-1.14）高甘油三酯血症的几率; a 1.22（95% CI：1.17-1.27）和1.15（95% CI：1.12-1.18）低HDL胆固醇的几率; a 1.19（95% CI：1.14-1.24）和1.10（95% CI：1.07 - 1.14）; S.结论：在美国和中国成年人中，NGS与心脏代谢疾病风险和身体残疾密切相关。S.中国老年人。
Background: Evidence highlights the importance of muscular strength as a protective factor for health and function across aging populations. The purpose of this study was to examine the extent to which low normalized grip strength (NGS) serves as a biomarker for both cardiometabolic disease and physical disability in U. S. and Chinese adults.Methods: Middle aged and older adults from the U. S. National Health and Nutrition Examination Survey 2011-2012 and 2013-2014 combined surveys (n = 4,544), and the 2011 wave of the China Health and Retirement Longitudinal Study (n = 6,030) were included. Strength was assessed using a handgrip dynamometer, and was normalized to body mass. Weighted logistic regression models were used to assess the association between NGS and diabetes, hyperglycemia, hypertriglyceridemia, low HDL-cholesterol, hypertension, and physical disability status, while controlling for age, sex, and sociodemographic characteristics.Results: Every 0.05 lower NGS was independently associated with a 1.49 (95% confidence interval [ CI]: 1.42-1.56) and 1.17 (95% CI: 1.11-1.23) odds for diabetes; a 1.46 (95% CI: 1.39-1.53) and 1.11 (95% CI: 1.07-1.15) odds of hyperglycemia; a 1.15 (95% CI: 1.07-1.25) and 1.11 (95% CI: 1.08-1.14) odds of hypertriglyceridemia; a 1.22 (95% CI: 1.17-1.27) and 1.15 (95% CI: 1.12-1.18) odds of low HDLcholesterol; a 1.19 (95% CI: 1.14-1.24) and 1.10 (95% CI: 1.07-1.14) odds of hypertension; and a 1.36 (95% CI: 1.29-1.42) and 1.10 (95% CI: 1.05-1.15) odds for physical disability status in U. S. and Chinese adults, respectively.Conclusions: NGS was robustly associated with both cardiometabolic disease risk and physical disabilities in U. S. and Chinese aging adults.