Folding control of a non-natural glycopeptide using saccharide-coded structural information for polypeptides
Folding control of a non-natural glycopeptide using saccharide-coded structural information for polypeptides
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使用多肽的糖编码结构信息对非天然糖肽的折叠控制
DOI：
10.1039/c9cc10030j
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发表时间：
2020
影响因子：
4.9
通讯作者：
Onitsuka Kiyotaka
中科院分区：
文献类型：
--
作者：
Ishido Yuki;Kanbayashi Naoya;Fujii Naoka;Okamura Taka-aki;Haino Takeharu;Onitsuka Kiyotaka
我们合成了“糖-芳基肽”，其折叠结构根据其侧链中糖的种类而显著变化。糖部分通过氢键与主链相互作用，并且非天然多肽形成两种明确定义的结构-（P）-31-和（M）-41-螺旋-这取决于糖链的长度，甚至取决于差向异构体中单个立体中心的构型。
We synthesized “glyco-arylopeptides”, whose folding structure significantly changes depending on the kind of saccharide in their side chain. The saccharide moiety interacts with the main chain via hydrogen bonding, and the non-natural polypeptides form two well-defined architectures—(P)-31- and (M)-41-helices—depending on the length of the saccharide chains and even the configuration of a single stereo-genic center in the epimers.