Nitric oxide may contribute to the long-term impairment of synaptic transmission after transient ischemia.
Nitric oxide may contribute to the long-term impairment of synaptic transmission after transient ischemia.
复制标题
一氧化氮可能导致短暂性缺血后突触传递的长期损害。
DOI：
10.1161/01.str.0000033074.40202.8e
复制
发表时间：
2002
期刊：
影响因子：
8.3
通讯作者：
Mongin,AA
中科院分区：
文献类型：
--
作者：
Mongin,AA
我们饶有兴趣地阅读了 Vliegenthart 等人关于中风和冠状动脉钙化之间关联的文章。冠状动脉钙化是否与脑动脉粥样硬化相关是令人感兴趣的。我们还认为冠状动脉钙化可能在脑梗塞的发生中发挥至关重要的作用。我们想展示冠状动脉钙化和脑动脉粥样硬化之间可能存在的关系，然后我们想将他们的研究与我们的研究进行比较。 2001年4月1日至2002年3月31日期间，在PL东京保健中心，31 646名日本受试者（19 901名男性和11 745名女性）接受了体检。其中，1 100名受试者（865名男性，245名女性）接受了脑部检查和胸部螺旋CT检查。男性平均年龄为 53.8 岁（SD，10.9 岁），男性为 54.0 岁（SD，10.8 岁），女性为 53.1 岁（SD，11.2 岁）。脑 MRI 和磁共振血管造影 (MRA) 由 1.5-Tesla 超导系统（Stratis II，Hitachi Medical Co）产生。在 MRI 上进行轴向 T1 加权（重复时间/回波时间 400/20 ms）和 T2 加权（重复时间/回波时间 4750/120 ms）图像。 MRI的切片/间隙厚度为6.0/0.5mm，矩阵大小为224256。采集数量为2。MRA采用3维飞行时间技术。切片厚度为0.6mm，基质尺寸为140140。螺旋CT使用CT-W3000(日立医疗公司)。切片厚度为5～10mm，矩阵尺寸为256256。扫描区域包括主动脉根部。切片总数为40。腔隙被定义为T1-低信号和T2-高信号区域(3mm直径15mm)。动脉粥样硬化MRA评分分为1～4级。1级（正常）大脑前动脉A3段、大脑中动脉M3-4段、大脑后动脉P3-4段血流信号强度显示清晰。在 2 级（轻度动脉粥样硬化）中，A3 段、M3 段或 P3 段远端部分的血流信号强度不明确。 3级（中度动脉粥样硬化），A3段远端、M3段远端或P3段远端没有血流信号强度。最后，在4级（严重动脉粥样硬化或阻塞）中，A3段的近端部分的A1段、M3段的近端部分的M1段或P3段的近端部分的P1段没有血流信号强度。大脑前动脉、中动脉和后动脉的总动脉粥样硬化评分为 3 至 12。一名经验丰富的神经科医生和两名诊断放射科医生检查了脑部 MRI 和 MRA。三位经验丰富的诊断放射科医生检查了胸部 CT。钙评分根据Agatston等人的方法测定。 2 冠状动脉钙化诊断为钙评分为 500，心外膜冠状动脉密度为 130 Hounsfield 单位。 149 名受试者（131 名男性，18 名女性）患有冠状动脉钙化。钙化发生率为12.5%，男性为14.2%，女性为6.5%。钙化组的平均年龄为63.9岁（SD，8.7岁），男性为63.1岁（SD，8.6岁），女性为70.3岁（SD，6.6岁）。非钙化组的年龄为52.3岁（SD，10.4岁），男性为52.4岁（SD，10.3岁），女性为51.9岁（SD，10.5岁）。糖尿病（空腹血糖 126 mg/dL 或当前药物治疗）、高血压（收缩压 140 mm Hg、舒张压 90 mm ...
We read with great interest the article by Vliegenthart et al1 concerning an association between stroke and coronary calcification. It is of interest whether coronary calcification is correlated with cerebral atherosclerosis. We also believe that coronary calcification could play a crucial role in the incidence of cerebral infarctions. We would like to show a possible relationship between coronary calcification and cerebral atherosclerosis and then we would like to compare their study and ours. At the PL Tokyo Health Care Center, 31 646 Japanese subjects (19 901 men and 11 745 women) received physical checkups between April 1, 2001, and March 31, 2002. Among them, brain checkup and helical CT of the chest were done in 1100 subjects (865 men, 245 women). Mean age was 53.8 years (SD, 10.9 years), 54.0 years (SD, 10.8 years) in men and 53.1 years (SD, 11.2 years) in women. Brain MRI and magnetic resonance angiography (MRA) were produced by a 1.5-Tesla superconducting system (Stratis II, Hitachi Medical Co). Axial T1-weighted (repetition time/echo time400/20 ms) and T2-weighted (repetition time/echo time4750/120 ms) images were performed on MRI. The slice/gap thickness of the MRI was 6.0/0.5 mm, and the matrix size was 224256. The number of acquisitions was 2. MRA was applied by 3-dimensional time-of-flight technique. The slice thickness was 0.6 mm, and the matrix size was 140140. Helical CT was used with CT-W3000 (Hitachi Medical Co). The slice thickness was 5 to 10 mm, and the matrix size was 256256. Scan areas included the root of aorta through the heat. The total number of slices was 40. Lacuna was defined as T1-hypointense and T2-hyperintense areas (3 mmdiameter15 mm). MRA score of atherosclerosis was classified from grade 1 to 4. In grade 1 (normal), blood flow signal intensities were displayed clearly in the A3 segment of the anterior cerebral artery, M3-4 segment of the middle cerebral artery, or P3-4 segment of the posterior cerebral artery. In grade 2 (mild atherosclerosis), blood flow signal intensities were seen equivocally in the distal portion of the A3 segment, M3 segment, or P3 segment. In grade 3 (moderate atherosclerosis), blood flow signal intensities were absent in the distal portion of the A3 segment, distal portion of the M3 segment, or distal portion of P3 segment. Finally, in grade 4 (severe atherosclerosis or obstruction), blood flow signal intensities were absent in the A1 segment of the proximal portion of A3 segment, M1 segment of the proximal portion of the M3 segment, or P1 segment of the proximal portion of P3 segment. Total atherosclerotic score was calculated as 3 to 12 in the anterior, middle, and posterior cerebral arteries. One experienced neurologist and 2 diagnostic radiologists reviewed brain MRI and MRA. Three experienced diagnostic radiologists reviewed chest CT. Calcium score was determined according to the method of Agatston et al. 2 Coronary calcification was diagnosed as calcium score 500 and a density of 130 Hounsfield units in the epicardial coronary arteries. One hundred forty-nine subjects (131 men, 18 women) had coronary calcification. The incidence of calcification was 12.5%, 14.2% in men and 6.5% in women. The mean age of the calcification group was 63.9 years (SD, 8.7 years), 63.1 years (SD, 8.6 years) in men and 70.3 years (SD, 6.6 years) in women. That of the noncalcification group was 52.3 years (SD, 10.4 years), 52.4 years (SD, 10.3 years) in men and 51.9 years (SD, 10.5 years) in women. The frequency of diabetes mellitus (fasting plasma glucose 126 mg/dL or current medication), hypertension (systolic pressure 140 mm Hg, diastolic pressure 90 mm …