Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy
Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy
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DOI：
10.1212/01.wnl.0000252813.86812.81
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发表时间：
2007-01-30
期刊：
影响因子：
9.9
通讯作者：
Kuzniecky, R. I.
中科院分区：
文献类型：
--
作者：
Gilliam, F. G.;Maton, B. M.;Kuzniecky, R. I.
目的：探讨海马功能指标与颞叶癫痫患者抑郁症状严重程度的关系。研究方法：我们评估了31例视频/脑电图证实的颞叶癫痫患者，使用肌酸/N-乙酰天冬氨酸比率图，该图来自先前验证的4.1 T H-1磁共振波谱成像（H-1-MRSI）技术。我们还评估了抑郁症症状、癫痫相关因素以及自我感知的社交和职业障碍。我们使用保守的非参数双变量程序来确定抑郁症状的严重程度与影像学和临床变量的相关性。结果如下：海马1H-MRSI异常的程度与抑郁症的严重程度相关（斯皮尔曼rho = 0.65，p值< 0.001），但其他临床因素与抑郁症的严重程度无关。结论：海马功能障碍的程度与颞叶癫痫的抑郁症状有关，可能是比癫痫发作频率或残疾程度更重要的因素。
Objective: To investigate the association of an indicator of hippocampal function with severity of depression symptoms in temporal lobe epilepsy. Methods: We evaluated 31 patients with video/EEG-confirmed temporal lobe epilepsy using creatine/N-acetylaspartate ratio maps derived from a previously validated H-1 magnetic resonance spectroscopic imaging (H-1-MRSI) technique at 4.1 T. We also assessed depression symptoms, epilepsy-related factors, and self-perceived social and vocational disability. We used conservative nonparametric bivariate procedures to determine the correlation of severity of depression symptoms with imaging and clinical variables. Results: The extent of hippocampal 1H-MRSI abnormalities correlated with severity of depression (Spearman rho = 0.65, p value < 0.001), but other clinical factors did not. Conclusion: The extent of hippocampal dysfunction is associated with depression symptoms in temporal lobe epilepsy and may be a more important factor than seizure frequency or degree of disability.