Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates
Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates
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DOI：
10.1128/jcm.43.4.1973-1976.2005
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发表时间：
2005-04-01
影响因子：
9.4
通讯作者：
O'Gara, JP
中科院分区：
文献类型：
--
作者：
Fitzpatrick, F;Humphreys, H;O'Gara, JP
通过icaADBC编码的酶合成多糖粘附素是目前最为人所知的葡萄球菌生物膜形成机制。在4个耐甲氧西林金黄色葡萄球菌分离株中，icaADBC的环境活化并不总是与生物膜产生增加相关。此外，这些分离株中葡萄糖介导的生物膜发育不依赖于icaADBC。显然，在S.金黄色葡萄球菌临床分离株。
Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.