Analysis of CD23 antigen expression in B-chronic lymphocytic leukaemia and its correlation with clinical parameters
Analysis of CD23 antigen expression in B-chronic lymphocytic leukaemia and its correlation with clinical parameters
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DOI：
10.1007/s12032-007-9038-7
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发表时间：
2008-09-01
期刊：
影响因子：
3.4
通讯作者：
Colovic, Milica
中科院分区：
文献类型：
--
作者：
Jurisic, Vladimir;Colovic, Natasa;Colovic, Milica
B-慢性淋巴细胞白血病(B-CLL)是一种以血液、骨髓和其他组织中积聚的终末分化的小而无能的B淋巴细胞为特征的单克隆性恶性肿瘤。CD23抗原是一种跨膜糖蛋白，可促进正常B淋巴细胞的活化和增殖，在B-CLL的恶变过程中起重要作用。这项回顾性队列研究连续77例新诊断的B-CLL患者，其中男性43例，女性34例，中位年龄62岁，检测CD23的表达及其与临床参数的相关性。CD23+与骨髓前淋巴细胞浸润(P<；0.01)和外周血淋巴细胞计数(P<；0.001)呈负相关。CD23低表达与血清免疫球蛋白水平降低相关(P<；0.05)，尤其是免疫球蛋白IgG；而CD23高表达与CD5水平高呈正相关。CD23+淋巴细胞和GT；40%的B-CLL患者的生存期(92.8月)明显长于CD2340%的患者(35.3月)(P=0.001)。CD23在B-CLL患者的淋巴细胞中不统一表达，其表达的差异取决于许多临床参数，包括外周血淋巴细胞计数和骨髓中淋巴细胞原的浸润程度。CD23的表达在淋巴细胞计数极高的患者(PBL计数为100×10(9)/1)和疾病的晚期显著降低。
B-Chronic lymphocytic leukaemia (B-CLL) is a monoclonal malignancy characterized by an accumulation of terminally differentiated small and anergic B lymphocytes in the blood, bone marrow and other tissues. CD23 antigen, a trans-membrane glycoprotein, promotes the activation and proliferation of normal B lymphocytes and has an important role in the process of malignant transformation in B-CLL. This retrospective cohort study of 77 consecutive newly diagnosed B-CLL patients, 43 males, 34 females, median age of 62 years, examined CD23 expression and correlations with clinical parameters. CD23+ was negatively correlated with pro-lymphocyte infiltration of the bone marrow (P < 0.01) and peripheral blood lymphocyte counts (P < 0.001). Lower CD23 expression was correlated with lower serum immunoglobulin levels (P < 0.05), especially IgG; while greater CD23 expression was positively correlated with higher CD5 levels. B-CLL patients with a percentage of CD23+ lymphocytes > 40% had longer survival (92.8 months) than those expressing < 40% (35.3 months) (P = 0.001). CD23 is not uniformly expressed by lymphocytes in B-CLL patients, and the differences in expression are dependent on a number of clinical parameters, including the peripheral blood lymphocyte count and the degree of pro-lymphocyte infiltration of the bone marrow. CD23 expression is significantly decreased in patients with extremely high lymphocyte counts (PBL counts of > 100 x10(9)/1) and in the advanced stages of disease.