The organization of proteins in the human red blood cell membrane. A review.
The organization of proteins in the human red blood cell membrane. A review.
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DOI：
10.1083/jcb.62.1.1
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发表时间：
1974-07
期刊：
影响因子：
--
通讯作者：
Steck TL
中科院分区：
文献类型：
--
作者：
Steck TL
阐明细胞膜的分子结构是细胞生物学的中心目标，因为结构是功能的核心。长期以来，红细胞膜一直为这一研究提供了有利的试验场。人的红细胞很容易获得，相对同质，与医学相关。它们的质膜可以很容易地完整地分离出来，基本上不受其他细胞、细胞器和细胞质内容物的污染。这种膜足够复杂，足以引起人们的兴趣，在某种程度上也具有代表性，但它又足够简单，可以作为一个整体进行分析。这些情况使得人类红细胞质膜很可能是第一个其分子解剖结构已知的令人满意的细节。有关红细胞膜和膜蛋白的文献一直是反复回顾的主题[19]。这篇文章将集中在单个主要多肽在人红细胞膜内的定位和结合方式。
The elucidation of the molecular architecture of cell membranes is a central goal for cell biology, as structure lies at the heart of function. The erythrocyte plasma membrane has long provided a favored testing ground for this inquiry. Human red blood cells are readily available, relatively homogeneous, and relevant to medicine. Their plasma membranes can be easily isolated intact and essentially free of contamination from other cells, organelles, and cytoplasmic contents. This membrane is complex enough to be interesting and, to some degree, representative, yet it is simple enough to be analyzed as a whole. These circumstances make it likely that the human red cell plasma membrane will be the first whose molecular anatomy is known in any degree of satisfying detail. The literature concerning the proteins of erythrocyte membranes and membranes in general has been the subject of repeated review (1 9). This article will focus on the localization and modes of association of individual major polypeptides within the human red cell membrane.